Three-dimensional structure of entire hydrated murine hearts at histological resolution

Three-dimensional structure of entire hydrated murine hearts at histological resolution

Abstract Imaging the entire cardiomyocyte network in entire small animal hearts at single cell resolution is a formidable challenge. Optical microscopy provides sufficient contrast and resolution in 2d, however fails to deliver non-destructive 3d reconstructions with isotropic resolution. It require...

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Bibliographic Details
Main Authors: Jasper Frohn, Frederik Böddeker, Marius Reichardt, Hendrik Bruns, Titus Czajka, Amara Khan, Ludovic Broche, Michael Krisch, Alberto Bravin, Frauke Alves, Jana Zschüntzsch, Tim Salditt
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Virtual 3d histology
Cardiomyocyte network
X-ray phase-contrast
X-ray tomography
Organ imaging
Online Access:https://doi.org/10.1038/s41598-024-83853-y
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