Highly efficient construction of angular polycycles
Abstract Angular tricyclic and polycyclic skeletons feature typical cores in an intriguing type of natural products. We herein report the Lewis acids-catalyzed dearomative (3 + 2) cycloadditions of donor-acceptor cyclopropanes with benzene ring, by which structurally complex and diverse angular tric...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-53562-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850203984929751040 |
|---|---|
| author | Yi Sun Xiaobing Huang Jun Ren Zhongwen Wang |
| author_facet | Yi Sun Xiaobing Huang Jun Ren Zhongwen Wang |
| author_sort | Yi Sun |
| collection | DOAJ |
| description | Abstract Angular tricyclic and polycyclic skeletons feature typical cores in an intriguing type of natural products. We herein report the Lewis acids-catalyzed dearomative (3 + 2) cycloadditions of donor-acceptor cyclopropanes with benzene ring, by which structurally complex and diverse angular tricyclic and polycyclic carbocycles were efficiently constructed from cheap and easily available feedstock and with convenient operation. This is also the example of (3 + 2) cycloaddition of a C3-synthon with the C = C of benzene. We believe this will demonstrate its potential in the total syntheses of natural products and drug discovery. |
| format | Article |
| id | doaj-art-7aaae431583d456dba72430ddcc70b60 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-7aaae431583d456dba72430ddcc70b602025-08-20T02:11:22ZengNature PortfolioNature Communications2041-17232024-10-011511810.1038/s41467-024-53562-1Highly efficient construction of angular polycyclesYi Sun0Xiaobing Huang1Jun Ren2Zhongwen Wang3State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityAbstract Angular tricyclic and polycyclic skeletons feature typical cores in an intriguing type of natural products. We herein report the Lewis acids-catalyzed dearomative (3 + 2) cycloadditions of donor-acceptor cyclopropanes with benzene ring, by which structurally complex and diverse angular tricyclic and polycyclic carbocycles were efficiently constructed from cheap and easily available feedstock and with convenient operation. This is also the example of (3 + 2) cycloaddition of a C3-synthon with the C = C of benzene. We believe this will demonstrate its potential in the total syntheses of natural products and drug discovery.https://doi.org/10.1038/s41467-024-53562-1 |
| spellingShingle | Yi Sun Xiaobing Huang Jun Ren Zhongwen Wang Highly efficient construction of angular polycycles Nature Communications |
| title | Highly efficient construction of angular polycycles |
| title_full | Highly efficient construction of angular polycycles |
| title_fullStr | Highly efficient construction of angular polycycles |
| title_full_unstemmed | Highly efficient construction of angular polycycles |
| title_short | Highly efficient construction of angular polycycles |
| title_sort | highly efficient construction of angular polycycles |
| url | https://doi.org/10.1038/s41467-024-53562-1 |
| work_keys_str_mv | AT yisun highlyefficientconstructionofangularpolycycles AT xiaobinghuang highlyefficientconstructionofangularpolycycles AT junren highlyefficientconstructionofangularpolycycles AT zhongwenwang highlyefficientconstructionofangularpolycycles |