A high-efficiency automatic pressure-relief drug transfer device for anticancer medications with superior closed performance
ObjectivePreventing exposure to hazardous drugs is crucial for healthcare workers to avoid health risks. To mitigate healthcare workers’ risks when handling hazardous drugs, we developed a novel closed-system drug-transfer device (CSTD) called CSTD(JLY). This CSTD has an automatic pressure-relief st...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1579771/full |
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| author | Liming Xie Guanfeng Chen Qianqian Ouyang Weiyan Quan Xiaoming Xie Xiaoling Chen Lefan Li Sidong Li Rizhi Chen Rongqiong Luo Zhiqing Qiu |
| author_facet | Liming Xie Guanfeng Chen Qianqian Ouyang Weiyan Quan Xiaoming Xie Xiaoling Chen Lefan Li Sidong Li Rizhi Chen Rongqiong Luo Zhiqing Qiu |
| author_sort | Liming Xie |
| collection | DOAJ |
| description | ObjectivePreventing exposure to hazardous drugs is crucial for healthcare workers to avoid health risks. To mitigate healthcare workers’ risks when handling hazardous drugs, we developed a novel closed-system drug-transfer device (CSTD) called CSTD(JLY). This CSTD has an automatic pressure-relief structure. Hence, it can significantly decrease the resistance in the push/pull of a piston rod if an operator transfers drugs, thereby reducing the burden on the hands of the operator during drug transfer.MethodsWe investigated the closed performance of the novel CSTD (JLY) by comparing it with the performance of a syringe. We selected a simulation drug (fluorescein sodium), commonly used drugs (lansoprazole, nimodipine, and tropisetron), and a commonly used anti-cancer agent (cyclophosphamide) to conduct exposure evaluation.ResultsCompared with a syringe, CSTD(JLY) could reduce drug leakage significantly. Our novel CSTD with an automatic pressure-relief structure had superior closed performance. CSTD(JLY) could solve the problem of liquid-drug leakage during drug transfer.ConclusionThis feature could reduce the exposure risk healthcare workers and patients. |
| format | Article |
| id | doaj-art-7aaa66a9e9714eb384f4449d1b89d24a |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-7aaa66a9e9714eb384f4449d1b89d24a2025-08-20T02:24:42ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-04-011610.3389/fphar.2025.15797711579771A high-efficiency automatic pressure-relief drug transfer device for anticancer medications with superior closed performanceLiming Xie0Guanfeng Chen1Qianqian Ouyang2Weiyan Quan3Xiaoming Xie4Xiaoling Chen5Lefan Li6Sidong Li7Rizhi Chen8Rongqiong Luo9Zhiqing Qiu10Department of Pharmacy, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Pharmacy, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaSchool of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, Guangdong, ChinaSchool of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Pharmacy, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Pharmacy, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaSchool of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang, ChinaSchool of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang, ChinaGuangdong Jianliyuan Medical Technology Co., Ltd., Zhanjiang, ChinaGuangdong Jianliyuan Medical Technology Co., Ltd., Zhanjiang, ChinaDepartment of Pharmacy, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaObjectivePreventing exposure to hazardous drugs is crucial for healthcare workers to avoid health risks. To mitigate healthcare workers’ risks when handling hazardous drugs, we developed a novel closed-system drug-transfer device (CSTD) called CSTD(JLY). This CSTD has an automatic pressure-relief structure. Hence, it can significantly decrease the resistance in the push/pull of a piston rod if an operator transfers drugs, thereby reducing the burden on the hands of the operator during drug transfer.MethodsWe investigated the closed performance of the novel CSTD (JLY) by comparing it with the performance of a syringe. We selected a simulation drug (fluorescein sodium), commonly used drugs (lansoprazole, nimodipine, and tropisetron), and a commonly used anti-cancer agent (cyclophosphamide) to conduct exposure evaluation.ResultsCompared with a syringe, CSTD(JLY) could reduce drug leakage significantly. Our novel CSTD with an automatic pressure-relief structure had superior closed performance. CSTD(JLY) could solve the problem of liquid-drug leakage during drug transfer.ConclusionThis feature could reduce the exposure risk healthcare workers and patients.https://www.frontiersin.org/articles/10.3389/fphar.2025.1579771/fullclosed performanceautomatic pressure-reliefhazardous drugsclosed-system drugtransfer deviceoccupational protectionCSTD |
| spellingShingle | Liming Xie Guanfeng Chen Qianqian Ouyang Weiyan Quan Xiaoming Xie Xiaoling Chen Lefan Li Sidong Li Rizhi Chen Rongqiong Luo Zhiqing Qiu A high-efficiency automatic pressure-relief drug transfer device for anticancer medications with superior closed performance Frontiers in Pharmacology closed performance automatic pressure-relief hazardous drugs closed-system drugtransfer device occupational protection CSTD |
| title | A high-efficiency automatic pressure-relief drug transfer device for anticancer medications with superior closed performance |
| title_full | A high-efficiency automatic pressure-relief drug transfer device for anticancer medications with superior closed performance |
| title_fullStr | A high-efficiency automatic pressure-relief drug transfer device for anticancer medications with superior closed performance |
| title_full_unstemmed | A high-efficiency automatic pressure-relief drug transfer device for anticancer medications with superior closed performance |
| title_short | A high-efficiency automatic pressure-relief drug transfer device for anticancer medications with superior closed performance |
| title_sort | high efficiency automatic pressure relief drug transfer device for anticancer medications with superior closed performance |
| topic | closed performance automatic pressure-relief hazardous drugs closed-system drugtransfer device occupational protection CSTD |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1579771/full |
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