Effect of <i>Satureja montana</i> Essential Oil on Model Lipid Membranes
<i>Satureja montana</i> essential oil is a natural substance able to inhibit the growth of several pathogens. This antimicrobial effect is often attributed to its ability to penetrate cellular structures and disrupt them. Although these properties are recognized as playing a key role in...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/15/1/5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588983271424000 |
|---|---|
| author | Simona Sennato Silvia Trabalzini Maria Gioia Fabiano Domenico Truzzolillo Edouard Chauveau Cecilia Bombelli Federica Rinaldi Maria Carafa |
| author_facet | Simona Sennato Silvia Trabalzini Maria Gioia Fabiano Domenico Truzzolillo Edouard Chauveau Cecilia Bombelli Federica Rinaldi Maria Carafa |
| author_sort | Simona Sennato |
| collection | DOAJ |
| description | <i>Satureja montana</i> essential oil is a natural substance able to inhibit the growth of several pathogens. This antimicrobial effect is often attributed to its ability to penetrate cellular structures and disrupt them. Although these properties are recognized as playing a key role in the mechanism of action of this substance, many unresolved issues still exist, and fundamental studies focused on such aspects are scarce. In this framework, we investigated the interaction of SEO with lipid monolayers, which represent simplified models of cell membranes, using the Langmuir monolayer technique, complemented by fluorescence anisotropy and differential scanning calorimetry on lipid bilayers. By focusing on packing conditions that approximate those of biological membranes and using lipids with different polar heads and structures, such as the ones occurring in bacterial membranes, we aim to clarify the effect of this essential oil on the lipid membrane. Our results show that <i>Satureja montana</i> essential oil consistently manages to insert into the membrane and interfere with the lipid–lipid interactions, thereby altering the lipid packing and significantly increasing the membrane fluidity, depending on the oil concentration and the nature of the lipid. |
| format | Article |
| id | doaj-art-7aa82e6ab45f4e36a346e0ae3bfa618c |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-7aa82e6ab45f4e36a346e0ae3bfa618c2025-01-24T13:24:49ZengMDPI AGBiomolecules2218-273X2024-12-01151510.3390/biom15010005Effect of <i>Satureja montana</i> Essential Oil on Model Lipid MembranesSimona Sennato0Silvia Trabalzini1Maria Gioia Fabiano2Domenico Truzzolillo3Edouard Chauveau4Cecilia Bombelli5Federica Rinaldi6Maria Carafa7CNR-Institute for Complex Systems, Piazzale Aldo Moro 5, 00185 Rome, ItalyDrug Chemistry and Technology Department, Sapienza University of Rome, Piazzale Aldo Moro 2, 00185 Rome, ItalyDrug Chemistry and Technology Department, Sapienza University of Rome, Piazzale Aldo Moro 2, 00185 Rome, ItalyLaboratoire Charles Coulomb, UMR 5221, CNRS–Université de Montpellier, 34095 Montpellier, FranceLaboratoire Charles Coulomb, UMR 5221, CNRS–Université de Montpellier, 34095 Montpellier, FranceCNR-Institute for Biological Systems, Secondary Office of Rome-Reaction Mechanisms, c/o Chemistry Department, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDrug Chemistry and Technology Department, Sapienza University of Rome, Piazzale Aldo Moro 2, 00185 Rome, ItalyDrug Chemistry and Technology Department, Sapienza University of Rome, Piazzale Aldo Moro 2, 00185 Rome, Italy<i>Satureja montana</i> essential oil is a natural substance able to inhibit the growth of several pathogens. This antimicrobial effect is often attributed to its ability to penetrate cellular structures and disrupt them. Although these properties are recognized as playing a key role in the mechanism of action of this substance, many unresolved issues still exist, and fundamental studies focused on such aspects are scarce. In this framework, we investigated the interaction of SEO with lipid monolayers, which represent simplified models of cell membranes, using the Langmuir monolayer technique, complemented by fluorescence anisotropy and differential scanning calorimetry on lipid bilayers. By focusing on packing conditions that approximate those of biological membranes and using lipids with different polar heads and structures, such as the ones occurring in bacterial membranes, we aim to clarify the effect of this essential oil on the lipid membrane. Our results show that <i>Satureja montana</i> essential oil consistently manages to insert into the membrane and interfere with the lipid–lipid interactions, thereby altering the lipid packing and significantly increasing the membrane fluidity, depending on the oil concentration and the nature of the lipid.https://www.mdpi.com/2218-273X/15/1/5<i>Satureja montana</i> essential oillipid monolayersLangmuir isothermlipid-oil interaction |
| spellingShingle | Simona Sennato Silvia Trabalzini Maria Gioia Fabiano Domenico Truzzolillo Edouard Chauveau Cecilia Bombelli Federica Rinaldi Maria Carafa Effect of <i>Satureja montana</i> Essential Oil on Model Lipid Membranes Biomolecules <i>Satureja montana</i> essential oil lipid monolayers Langmuir isotherm lipid-oil interaction |
| title | Effect of <i>Satureja montana</i> Essential Oil on Model Lipid Membranes |
| title_full | Effect of <i>Satureja montana</i> Essential Oil on Model Lipid Membranes |
| title_fullStr | Effect of <i>Satureja montana</i> Essential Oil on Model Lipid Membranes |
| title_full_unstemmed | Effect of <i>Satureja montana</i> Essential Oil on Model Lipid Membranes |
| title_short | Effect of <i>Satureja montana</i> Essential Oil on Model Lipid Membranes |
| title_sort | effect of i satureja montana i essential oil on model lipid membranes |
| topic | <i>Satureja montana</i> essential oil lipid monolayers Langmuir isotherm lipid-oil interaction |
| url | https://www.mdpi.com/2218-273X/15/1/5 |
| work_keys_str_mv | AT simonasennato effectofisaturejamontanaiessentialoilonmodellipidmembranes AT silviatrabalzini effectofisaturejamontanaiessentialoilonmodellipidmembranes AT mariagioiafabiano effectofisaturejamontanaiessentialoilonmodellipidmembranes AT domenicotruzzolillo effectofisaturejamontanaiessentialoilonmodellipidmembranes AT edouardchauveau effectofisaturejamontanaiessentialoilonmodellipidmembranes AT ceciliabombelli effectofisaturejamontanaiessentialoilonmodellipidmembranes AT federicarinaldi effectofisaturejamontanaiessentialoilonmodellipidmembranes AT mariacarafa effectofisaturejamontanaiessentialoilonmodellipidmembranes |