Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice.
<h4>Aims</h4>To determine the impact of maternal and post-weaning consumption of a high fat diet on endothelium-dependent vasorelaxation and redox regulation in adult male mouse offspring.<h4>Methods</h4>Female C57BL6J mice were fed an obesogenic high fat diet (HF, 45% kcal f...
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0050671&type=printable |
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| author | Christopher Torrens Priya Ethirajan Kimberley D Bruce Felino R A Cagampang Richard C M Siow Mark A Hanson Christopher D Byrne Giovanni E Mann Geraldine F Clough |
| author_facet | Christopher Torrens Priya Ethirajan Kimberley D Bruce Felino R A Cagampang Richard C M Siow Mark A Hanson Christopher D Byrne Giovanni E Mann Geraldine F Clough |
| author_sort | Christopher Torrens |
| collection | DOAJ |
| description | <h4>Aims</h4>To determine the impact of maternal and post-weaning consumption of a high fat diet on endothelium-dependent vasorelaxation and redox regulation in adult male mouse offspring.<h4>Methods</h4>Female C57BL6J mice were fed an obesogenic high fat diet (HF, 45% kcal fat) or standard chow (C, 21% kcal fat) pre-conception and throughout pregnancy and lactation. Post-weaning, male offspring were continued on the same diet as their mothers or placed on the alternative diet to give 4 dietary groups (C/C, HF/C, C/HF and HF/HF) which were studied at 15 or 30 weeks of age.<h4>Results</h4>There were significant effects of maternal diet on offspring body weight (p<0.004), systolic blood pressure (p = 0.026) and endothelium-dependent relaxation to ACh (p = 0.004) and NO production (p = 0.005) measured in the femoral artery. With control for maternal diet there was also an effect of offspring post-weaning dietary fat to increase systolic blood pressure (p<0.0001) and reduce endothelium-dependent relaxation (p = 0.022) and ACh-mediated NO production (p = 0.007). There was also a significant impact of age (p<0.005). Redox balance was perturbed, with altered regulation of vascular enzymes involved in ROS/NO signalling.<h4>Conclusions</h4>Maternal consumption of a HF diet is associated with changes in vascular function and oxidative balance in the offspring of similar magnitude to those seen with consumption of a high fat diet post-weaning. Further, this disadvantageous vascular phenotype is exacerbated by age to influence the risk of developing obesity, raised blood pressure and endothelial dysfunction in adult life. |
| format | Article |
| id | doaj-art-7aa78ed44a7a46f68af749261107a037 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-7aa78ed44a7a46f68af749261107a0372025-08-20T02:05:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5067110.1371/journal.pone.0050671Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice.Christopher TorrensPriya EthirajanKimberley D BruceFelino R A CagampangRichard C M SiowMark A HansonChristopher D ByrneGiovanni E MannGeraldine F Clough<h4>Aims</h4>To determine the impact of maternal and post-weaning consumption of a high fat diet on endothelium-dependent vasorelaxation and redox regulation in adult male mouse offspring.<h4>Methods</h4>Female C57BL6J mice were fed an obesogenic high fat diet (HF, 45% kcal fat) or standard chow (C, 21% kcal fat) pre-conception and throughout pregnancy and lactation. Post-weaning, male offspring were continued on the same diet as their mothers or placed on the alternative diet to give 4 dietary groups (C/C, HF/C, C/HF and HF/HF) which were studied at 15 or 30 weeks of age.<h4>Results</h4>There were significant effects of maternal diet on offspring body weight (p<0.004), systolic blood pressure (p = 0.026) and endothelium-dependent relaxation to ACh (p = 0.004) and NO production (p = 0.005) measured in the femoral artery. With control for maternal diet there was also an effect of offspring post-weaning dietary fat to increase systolic blood pressure (p<0.0001) and reduce endothelium-dependent relaxation (p = 0.022) and ACh-mediated NO production (p = 0.007). There was also a significant impact of age (p<0.005). Redox balance was perturbed, with altered regulation of vascular enzymes involved in ROS/NO signalling.<h4>Conclusions</h4>Maternal consumption of a HF diet is associated with changes in vascular function and oxidative balance in the offspring of similar magnitude to those seen with consumption of a high fat diet post-weaning. Further, this disadvantageous vascular phenotype is exacerbated by age to influence the risk of developing obesity, raised blood pressure and endothelial dysfunction in adult life.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0050671&type=printable |
| spellingShingle | Christopher Torrens Priya Ethirajan Kimberley D Bruce Felino R A Cagampang Richard C M Siow Mark A Hanson Christopher D Byrne Giovanni E Mann Geraldine F Clough Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice. PLoS ONE |
| title | Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice. |
| title_full | Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice. |
| title_fullStr | Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice. |
| title_full_unstemmed | Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice. |
| title_short | Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice. |
| title_sort | interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0050671&type=printable |
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