Association between the difference in estimated GFR based on cystatin C versus creatinine in coronary artery diseases
Background The difference in estimated glomerular filtration rate (eGFR) derived from creatinine and cystatin C (eGFRdiff) has been noticed recently and the relationship with poor cardiovascular prognosis has been proven. However, primary prevention of the risk of coronary artery disease (CAD) is eq...
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2482127 |
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| author | Zechen Liu Wangying Jiang Yanjun Song Kefei Dou Weihua Song |
| author_facet | Zechen Liu Wangying Jiang Yanjun Song Kefei Dou Weihua Song |
| author_sort | Zechen Liu |
| collection | DOAJ |
| description | Background The difference in estimated glomerular filtration rate (eGFR) derived from creatinine and cystatin C (eGFRdiff) has been noticed recently and the relationship with poor cardiovascular prognosis has been proven. However, primary prevention of the risk of coronary artery disease (CAD) is equally important but there is a lack of studies specifically investigating this implication.Methods This prospective cohort study utilized data from the UK Biobank, including 437,536 participants without CAD at baseline. The primary outcome was defined as CAD. The eGFRdiff was calculated by subtracting creatinine-based eGFR from cystatin C-based eGFR. Participants were then categorized into a negative, intermediate range, and positive group based on thresholds of −15 mL/min/1.73 m2 and 15 mL/min/1.73 m2. Cox proportional risk models were used to evaluate the associations of eGFRdiff with CAD and the relationship among different genetic risks of CAD.Results During a median follow-up of 13.8 years, CAD occurred in 36,797 participants. In the fully adjusted model, compared to midrange eGFRdiff, participants with a positive eGFRdiff had a lower risk of CAD (HR 0.717, 95%CI 0.675-0.762), while with a negative eGFRdiff had a higher risk (HR 1.433, 95%CI 1.399-1.468). When eGFRdiff was treated as a continuous variable, a statistically significant trend toward a lower risk of CAD as eGFRdiff increased (HR 0.982, 95% CI 0.981-0.982). Moreover, this relationship is independent of genetic susceptibility.Conclusions eGFRdiff was associated with CAD risk, where a high eGFRdiff corresponded to a decreased likelihood of CAD onset no matter genetic susceptibility. |
| format | Article |
| id | doaj-art-7aa1759bf99c4d419f565f669f8eda7a |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-7aa1759bf99c4d419f565f669f8eda7a2025-08-20T03:19:08ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2482127Association between the difference in estimated GFR based on cystatin C versus creatinine in coronary artery diseasesZechen Liu0Wangying Jiang1Yanjun Song2Kefei Dou3Weihua Song4Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College/National Center for Cardiovascular Diseases, Beijing, ChinaFuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College/National Center for Cardiovascular Diseases, Beijing, ChinaFuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College/National Center for Cardiovascular Diseases, Beijing, ChinaFuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College/National Center for Cardiovascular Diseases, Beijing, ChinaFuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College/National Center for Cardiovascular Diseases, Beijing, ChinaBackground The difference in estimated glomerular filtration rate (eGFR) derived from creatinine and cystatin C (eGFRdiff) has been noticed recently and the relationship with poor cardiovascular prognosis has been proven. However, primary prevention of the risk of coronary artery disease (CAD) is equally important but there is a lack of studies specifically investigating this implication.Methods This prospective cohort study utilized data from the UK Biobank, including 437,536 participants without CAD at baseline. The primary outcome was defined as CAD. The eGFRdiff was calculated by subtracting creatinine-based eGFR from cystatin C-based eGFR. Participants were then categorized into a negative, intermediate range, and positive group based on thresholds of −15 mL/min/1.73 m2 and 15 mL/min/1.73 m2. Cox proportional risk models were used to evaluate the associations of eGFRdiff with CAD and the relationship among different genetic risks of CAD.Results During a median follow-up of 13.8 years, CAD occurred in 36,797 participants. In the fully adjusted model, compared to midrange eGFRdiff, participants with a positive eGFRdiff had a lower risk of CAD (HR 0.717, 95%CI 0.675-0.762), while with a negative eGFRdiff had a higher risk (HR 1.433, 95%CI 1.399-1.468). When eGFRdiff was treated as a continuous variable, a statistically significant trend toward a lower risk of CAD as eGFRdiff increased (HR 0.982, 95% CI 0.981-0.982). Moreover, this relationship is independent of genetic susceptibility.Conclusions eGFRdiff was associated with CAD risk, where a high eGFRdiff corresponded to a decreased likelihood of CAD onset no matter genetic susceptibility.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2482127coronary artery diseaseestimated glomerular filtration ratecreatininecystatin CUK biobank |
| spellingShingle | Zechen Liu Wangying Jiang Yanjun Song Kefei Dou Weihua Song Association between the difference in estimated GFR based on cystatin C versus creatinine in coronary artery diseases Renal Failure coronary artery disease estimated glomerular filtration rate creatinine cystatin C UK biobank |
| title | Association between the difference in estimated GFR based on cystatin C versus creatinine in coronary artery diseases |
| title_full | Association between the difference in estimated GFR based on cystatin C versus creatinine in coronary artery diseases |
| title_fullStr | Association between the difference in estimated GFR based on cystatin C versus creatinine in coronary artery diseases |
| title_full_unstemmed | Association between the difference in estimated GFR based on cystatin C versus creatinine in coronary artery diseases |
| title_short | Association between the difference in estimated GFR based on cystatin C versus creatinine in coronary artery diseases |
| title_sort | association between the difference in estimated gfr based on cystatin c versus creatinine in coronary artery diseases |
| topic | coronary artery disease estimated glomerular filtration rate creatinine cystatin C UK biobank |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2482127 |
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