THE ROLE OF CYTOKINE SYSTEM RANKL-RANK-OPG AND CATHEPSIN K IN THE PATHOGENESIS OF OSTEOPOROSIS: ACHIEVEMENTS AND PERSPECTIVES IN THE TREATMENT OF DISEASE
The article presents review of literature dedicated to the contemporary view on the cellular-molecular mechanisms of the bone remodeling and pathogenesis of the osteoporosis. The discovery of the cytokine RANKL-RANK-OPG system and significant role of the cathepsin K in process bone remodeling has ma...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2015-10-01
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| Series: | Klinicist |
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| Online Access: | https://klinitsist.abvpress.ru/Klin/article/view/213 |
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| _version_ | 1849396846304165888 |
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| author | S. Sagalovsky P. Kunze M. Schönert |
| author_facet | S. Sagalovsky P. Kunze M. Schönert |
| author_sort | S. Sagalovsky |
| collection | DOAJ |
| description | The article presents review of literature dedicated to the contemporary view on the cellular-molecular mechanisms of the bone remodeling and pathogenesis of the osteoporosis. The discovery of the cytokine RANKL-RANK-OPG system and significant role of the cathepsin K in process bone remodeling has made progress in understanding the mechanisms development disease and possible to development drugs of the new generation – denosumab, a fully human RANKL monoclonal antibody and inhibitor cathepsin K odanacatib that inhibits of the bone resorption. |
| format | Article |
| id | doaj-art-7a980ae1930a43f5a7684949f4e7e68a |
| institution | Kabale University |
| issn | 1818-8338 |
| language | Russian |
| publishDate | 2015-10-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Klinicist |
| spelling | doaj-art-7a980ae1930a43f5a7684949f4e7e68a2025-08-20T03:39:14ZrusABV-pressKlinicist1818-83382015-10-016291610.17650/1818-8338-2012-6-2-9-16208THE ROLE OF CYTOKINE SYSTEM RANKL-RANK-OPG AND CATHEPSIN K IN THE PATHOGENESIS OF OSTEOPOROSIS: ACHIEVEMENTS AND PERSPECTIVES IN THE TREATMENT OF DISEASES. Sagalovsky0P. Kunze1M. Schönert2Median Klinik, Bad Lausick, GermanyMedian Klinik, Bad Lausick, GermanyMedian Klinik, Bad Lausick, GermanyThe article presents review of literature dedicated to the contemporary view on the cellular-molecular mechanisms of the bone remodeling and pathogenesis of the osteoporosis. The discovery of the cytokine RANKL-RANK-OPG system and significant role of the cathepsin K in process bone remodeling has made progress in understanding the mechanisms development disease and possible to development drugs of the new generation – denosumab, a fully human RANKL monoclonal antibody and inhibitor cathepsin K odanacatib that inhibits of the bone resorption.https://klinitsist.abvpress.ru/Klin/article/view/213bone remodelingsystem rankl-rank-opgcathepsin kosteoporosisdenosumabodanacatib |
| spellingShingle | S. Sagalovsky P. Kunze M. Schönert THE ROLE OF CYTOKINE SYSTEM RANKL-RANK-OPG AND CATHEPSIN K IN THE PATHOGENESIS OF OSTEOPOROSIS: ACHIEVEMENTS AND PERSPECTIVES IN THE TREATMENT OF DISEASE Klinicist bone remodeling system rankl-rank-opg cathepsin k osteoporosis denosumab odanacatib |
| title | THE ROLE OF CYTOKINE SYSTEM RANKL-RANK-OPG AND CATHEPSIN K IN THE PATHOGENESIS OF OSTEOPOROSIS: ACHIEVEMENTS AND PERSPECTIVES IN THE TREATMENT OF DISEASE |
| title_full | THE ROLE OF CYTOKINE SYSTEM RANKL-RANK-OPG AND CATHEPSIN K IN THE PATHOGENESIS OF OSTEOPOROSIS: ACHIEVEMENTS AND PERSPECTIVES IN THE TREATMENT OF DISEASE |
| title_fullStr | THE ROLE OF CYTOKINE SYSTEM RANKL-RANK-OPG AND CATHEPSIN K IN THE PATHOGENESIS OF OSTEOPOROSIS: ACHIEVEMENTS AND PERSPECTIVES IN THE TREATMENT OF DISEASE |
| title_full_unstemmed | THE ROLE OF CYTOKINE SYSTEM RANKL-RANK-OPG AND CATHEPSIN K IN THE PATHOGENESIS OF OSTEOPOROSIS: ACHIEVEMENTS AND PERSPECTIVES IN THE TREATMENT OF DISEASE |
| title_short | THE ROLE OF CYTOKINE SYSTEM RANKL-RANK-OPG AND CATHEPSIN K IN THE PATHOGENESIS OF OSTEOPOROSIS: ACHIEVEMENTS AND PERSPECTIVES IN THE TREATMENT OF DISEASE |
| title_sort | role of cytokine system rankl rank opg and cathepsin k in the pathogenesis of osteoporosis achievements and perspectives in the treatment of disease |
| topic | bone remodeling system rankl-rank-opg cathepsin k osteoporosis denosumab odanacatib |
| url | https://klinitsist.abvpress.ru/Klin/article/view/213 |
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