Low-dose extracorporeal shock wave attenuates sepsis-related acute lung injury by targeting mitochondrial dysfunction and pyroptosis crosstalk in type II alveolar epithelial cells

Low-dose extracorporeal shock wave attenuates sepsis-related acute lung injury by targeting mitochondrial dysfunction and pyroptosis crosstalk in type II alveolar epithelial cells

IntroductionThe pathological mechanism of sepsis-related acute lung injury (ALI) is closely linked to mitochondrial dysfunction and pyroptosis. Although low-dose extracorporeal shock wave (SW) therapy has been widely utilized in tissue and organ injury repair, its role in sepsis-related ALI remains...

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Main Authors: Jianning Guo, Xiaoxuan Qu, Ruidong Ge, Die Liu, Jing Liu, Qin Hui, Fang Ye, Yuanmei Chen, Chao Wang, Di Lv, Lijuan Tang, Meihong Xia, Qi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
shock wave
sepsis
acute lung injury
type II alveolar epithelial cell
mitochondrial DNA
pyroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1637378/full
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