A 23-gene multi-omics signature predicts prognosis and treatment response in non-small cell lung cancer

A 23-gene multi-omics signature predicts prognosis and treatment response in non-small cell lung cancer

Abstract Background We developed the first multi-omics prognostic signature integrating 19 programmed cell death (PCD) pathways and organelle functions (mitochondria, lysosomes, Golgi apparatus) to predict prognosis and immunotherapy response in non-small cell lung cancer (NSCLC). (2) Methods: By co...

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Bibliographic Details
Main Authors: Yinxu Zhang, Siwang Wang, Xiaoyang Chen, Guangyu Zhang, Yuxi Wang, Xiaomei Liu
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
Subjects:
Non-small cell lung cancer
Programmed cell death
Organelle function
Single-cell analysis
Machine learning
Prognosis
Online Access:https://doi.org/10.1007/s12672-025-03243-2
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