Sex differences in the relationship between body composition and MASLD progression in a murine model of metabolic syndrome
Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) progression exhibits significant sex differences, with males generally developing more severe disease. This study used an endothelial nitric oxide synthase knockout (eNOS KO) murine model to investigate sex-specific MASLD prog...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225001233 |
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| author | Laura Manjarrés Aline Xavier Leticia González Camila Garrido Flavia C. Zacconi Katherine Rivera Laura Parra Alkystis Phinikaridou Cecilia Besa Marcelo E. Andia |
| author_facet | Laura Manjarrés Aline Xavier Leticia González Camila Garrido Flavia C. Zacconi Katherine Rivera Laura Parra Alkystis Phinikaridou Cecilia Besa Marcelo E. Andia |
| author_sort | Laura Manjarrés |
| collection | DOAJ |
| description | Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) progression exhibits significant sex differences, with males generally developing more severe disease. This study used an endothelial nitric oxide synthase knockout (eNOS KO) murine model to investigate sex-specific MASLD progression under a Western diet intervention. Magnetic resonance imaging (MRI) assessed body composition and liver and skeletal muscle fat fraction, revealing greater visceral fat, liver volume, and liver-to-muscle fat ratios in males. Dimensionality reduction and clustering analyses identified distinct sex-specific MASLD phenotypes and progression patterns. Histological evaluations confirmed greater liver damage in males, evidenced by higher MAFLD Activity Scores. These findings highlight the critical role of sex as a biological variable in MASLD pathology and emphasize the influence of body composition and fat distribution on disease progression. The study underscores the utility of advanced imaging and analytical techniques for refining non-invasive diagnostics and guiding sex-specific interventions, paving the way for personalized MASLD management strategies. |
| format | Article |
| id | doaj-art-7a8b9011f15a4858868aa6f92f624907 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-7a8b9011f15a4858868aa6f92f6249072025-02-05T04:32:32ZengElsevieriScience2589-00422025-02-01282111863Sex differences in the relationship between body composition and MASLD progression in a murine model of metabolic syndromeLaura Manjarrés0Aline Xavier1Leticia González2Camila Garrido3Flavia C. Zacconi4Katherine Rivera5Laura Parra6Alkystis Phinikaridou7Cecilia Besa8Marcelo E. Andia9PhD Program in Medical Sciences, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile; Millennium Institute for Intelligent Healthcare Engineering, i-Health, Santiago, ChileFaculty of Engineering, Universidad de Santiago de Chile, Santiago, ChileMillennium Institute for Intelligent Healthcare Engineering, i-Health, Santiago, Chile; Biomedical Imaging Center and Radiology Department, School of Medicine. Pontificia Universidad Católica de Chile, Santiago, ChileMillennium Institute for Intelligent Healthcare Engineering, i-Health, Santiago, Chile; Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Santiago, ChileFaculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Santiago, ChileMillennium Institute for Intelligent Healthcare Engineering, i-Health, Santiago, ChileMillennium Institute for Intelligent Healthcare Engineering, i-Health, Santiago, ChileSchool of Biomedical Engineering and Imaging Sciences, King’s College London, London, UKMillennium Institute for Intelligent Healthcare Engineering, i-Health, Santiago, Chile; Biomedical Imaging Center and Radiology Department, School of Medicine. Pontificia Universidad Católica de Chile, Santiago, ChileMillennium Institute for Intelligent Healthcare Engineering, i-Health, Santiago, Chile; Biomedical Imaging Center and Radiology Department, School of Medicine. Pontificia Universidad Católica de Chile, Santiago, Chile; Corresponding authorSummary: Metabolic dysfunction-associated steatotic liver disease (MASLD) progression exhibits significant sex differences, with males generally developing more severe disease. This study used an endothelial nitric oxide synthase knockout (eNOS KO) murine model to investigate sex-specific MASLD progression under a Western diet intervention. Magnetic resonance imaging (MRI) assessed body composition and liver and skeletal muscle fat fraction, revealing greater visceral fat, liver volume, and liver-to-muscle fat ratios in males. Dimensionality reduction and clustering analyses identified distinct sex-specific MASLD phenotypes and progression patterns. Histological evaluations confirmed greater liver damage in males, evidenced by higher MAFLD Activity Scores. These findings highlight the critical role of sex as a biological variable in MASLD pathology and emphasize the influence of body composition and fat distribution on disease progression. The study underscores the utility of advanced imaging and analytical techniques for refining non-invasive diagnostics and guiding sex-specific interventions, paving the way for personalized MASLD management strategies.http://www.sciencedirect.com/science/article/pii/S2589004225001233GeneticsHuman metabolism |
| spellingShingle | Laura Manjarrés Aline Xavier Leticia González Camila Garrido Flavia C. Zacconi Katherine Rivera Laura Parra Alkystis Phinikaridou Cecilia Besa Marcelo E. Andia Sex differences in the relationship between body composition and MASLD progression in a murine model of metabolic syndrome iScience Genetics Human metabolism |
| title | Sex differences in the relationship between body composition and MASLD progression in a murine model of metabolic syndrome |
| title_full | Sex differences in the relationship between body composition and MASLD progression in a murine model of metabolic syndrome |
| title_fullStr | Sex differences in the relationship between body composition and MASLD progression in a murine model of metabolic syndrome |
| title_full_unstemmed | Sex differences in the relationship between body composition and MASLD progression in a murine model of metabolic syndrome |
| title_short | Sex differences in the relationship between body composition and MASLD progression in a murine model of metabolic syndrome |
| title_sort | sex differences in the relationship between body composition and masld progression in a murine model of metabolic syndrome |
| topic | Genetics Human metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225001233 |
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