Relationship between adverse childhood experiences and Alzheimer’s disease: a systematic review and meta-analysis protocol
Introduction Alzheimer’s disease has a high prevalence and a substantial impact on society, as well as the individual. Findings from clinical studies to date, suggest that multiple factors are likely to contribute to the variability seen in the progression of Alzheimer’s disease. However, despite th...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2021-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/8/e049768.full |
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| author | Julie A Pasco Lana J Williams Amanda L Stuart Behnaz Azimi Manavi Shae E Quirk Kayla B Corney Emma C West |
| author_facet | Julie A Pasco Lana J Williams Amanda L Stuart Behnaz Azimi Manavi Shae E Quirk Kayla B Corney Emma C West |
| author_sort | Julie A Pasco |
| collection | DOAJ |
| description | Introduction Alzheimer’s disease has a high prevalence and a substantial impact on society, as well as the individual. Findings from clinical studies to date, suggest that multiple factors are likely to contribute to the variability seen in the progression of Alzheimer’s disease. However, despite this accumulating evidence, current identified factors do not explain the full extent of disease onset. Thus, the role of additional factors needs to be explored further.One such factor is exposure to adverse childhood experiences. However, the degree of this association is unknown. This systematic review will examine the literature investigating the associations between adverse childhood experiences and the risk of Alzheimer’s disease.Methods and analysis Articles investigating associations between exposure to adverse childhood experiences and the risk of Alzheimer’s disease will be identified systematically by searching CINAHL, MEDLINE and PsycInfo using Ebscohost. No restrictions on date of publication will be applied. The search strategy will be built combining the main key elements of the Population, Exposure, Comparator, and Outcomes inclusion criteria. A meta-analysis is planned and statistical methods will be used to identify and control for heterogeneity, if possible. The development of this protocol was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols.Ethics and dissemination Only published data will be used for this study, thus, ethical approval will not be required. Findings of the review will be published in a peer-reviewed scientific journal, and presented at national and international conferences.PROSPERO registration number CRD42020191439. |
| format | Article |
| id | doaj-art-7a8ae63b166f4fdfba5383ed0e9af140 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-7a8ae63b166f4fdfba5383ed0e9af1402025-08-20T02:20:57ZengBMJ Publishing GroupBMJ Open2044-60552021-08-0111810.1136/bmjopen-2021-049768Relationship between adverse childhood experiences and Alzheimer’s disease: a systematic review and meta-analysis protocolJulie A Pasco0Lana J Williams1Amanda L Stuart2Behnaz Azimi Manavi3Shae E Quirk4Kayla B Corney5Emma C West6Barwon Health, Geelong, Victoria, AustraliaIMPACT – Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, AustraliaIMPACT—Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria, AustraliaDeakin University, IMPACT – Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Victoria, Australia1 Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, AustraliaIMPACT – Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, AustraliaIMPACT – Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, AustraliaIntroduction Alzheimer’s disease has a high prevalence and a substantial impact on society, as well as the individual. Findings from clinical studies to date, suggest that multiple factors are likely to contribute to the variability seen in the progression of Alzheimer’s disease. However, despite this accumulating evidence, current identified factors do not explain the full extent of disease onset. Thus, the role of additional factors needs to be explored further.One such factor is exposure to adverse childhood experiences. However, the degree of this association is unknown. This systematic review will examine the literature investigating the associations between adverse childhood experiences and the risk of Alzheimer’s disease.Methods and analysis Articles investigating associations between exposure to adverse childhood experiences and the risk of Alzheimer’s disease will be identified systematically by searching CINAHL, MEDLINE and PsycInfo using Ebscohost. No restrictions on date of publication will be applied. The search strategy will be built combining the main key elements of the Population, Exposure, Comparator, and Outcomes inclusion criteria. A meta-analysis is planned and statistical methods will be used to identify and control for heterogeneity, if possible. The development of this protocol was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols.Ethics and dissemination Only published data will be used for this study, thus, ethical approval will not be required. Findings of the review will be published in a peer-reviewed scientific journal, and presented at national and international conferences.PROSPERO registration number CRD42020191439.https://bmjopen.bmj.com/content/11/8/e049768.full |
| spellingShingle | Julie A Pasco Lana J Williams Amanda L Stuart Behnaz Azimi Manavi Shae E Quirk Kayla B Corney Emma C West Relationship between adverse childhood experiences and Alzheimer’s disease: a systematic review and meta-analysis protocol BMJ Open |
| title | Relationship between adverse childhood experiences and Alzheimer’s disease: a systematic review and meta-analysis protocol |
| title_full | Relationship between adverse childhood experiences and Alzheimer’s disease: a systematic review and meta-analysis protocol |
| title_fullStr | Relationship between adverse childhood experiences and Alzheimer’s disease: a systematic review and meta-analysis protocol |
| title_full_unstemmed | Relationship between adverse childhood experiences and Alzheimer’s disease: a systematic review and meta-analysis protocol |
| title_short | Relationship between adverse childhood experiences and Alzheimer’s disease: a systematic review and meta-analysis protocol |
| title_sort | relationship between adverse childhood experiences and alzheimer s disease a systematic review and meta analysis protocol |
| url | https://bmjopen.bmj.com/content/11/8/e049768.full |
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