Interactions Between Iron Metabolism and the Endocannabinoid System in Bacterial Infections
Iron is a key nutritional requirement for a variety of physiological functions, and its metabolism is tightly controlled under homeostatic conditions. The endocannabinoid system (ECS) represents an additional physiological system with a key role in maintaining homeostasis that is known for its role...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/14/6/614 |
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| author | Kayle Brenna Dickson Juan Zhou Christian Lehmann |
| author_facet | Kayle Brenna Dickson Juan Zhou Christian Lehmann |
| author_sort | Kayle Brenna Dickson |
| collection | DOAJ |
| description | Iron is a key nutritional requirement for a variety of physiological functions, and its metabolism is tightly controlled under homeostatic conditions. The endocannabinoid system (ECS) represents an additional physiological system with a key role in maintaining homeostasis that is known for its role in modulating immune responses. Recent research has highlighted intriguing interactions between these systems, including the suppression of iron uptake by the ECS and alterations to the iron-catalyzed Fenton reaction. These interactions are particularly interesting in the context of bacterial infections. As iron is a vital nutrient for bacteria, modulating iron levels using the ECS may be able to control bacterial growth. This review aims to explore the current understanding of how the ECS affects iron homeostasis and its implications for bacterial pathogenesis. In this study, we provide an overview of both iron metabolism and the ECS, focusing on harnessing these systems to develop novel therapeutic strategies to modulate iron metabolism in bacterial infections. By elucidating these complex interactions, we hope to provide new insights into the development of novel treatments for bacterial infections. |
| format | Article |
| id | doaj-art-7a85f00db0ba4e72a7968a05b39c9e7b |
| institution | Kabale University |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-7a85f00db0ba4e72a7968a05b39c9e7b2025-08-20T03:26:15ZengMDPI AGAntibiotics2079-63822025-06-0114661410.3390/antibiotics14060614Interactions Between Iron Metabolism and the Endocannabinoid System in Bacterial InfectionsKayle Brenna Dickson0Juan Zhou1Christian Lehmann2Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4R2, CanadaDepartment of Anesthesiology, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS B3H 4R2, CanadaDepartment of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4R2, CanadaIron is a key nutritional requirement for a variety of physiological functions, and its metabolism is tightly controlled under homeostatic conditions. The endocannabinoid system (ECS) represents an additional physiological system with a key role in maintaining homeostasis that is known for its role in modulating immune responses. Recent research has highlighted intriguing interactions between these systems, including the suppression of iron uptake by the ECS and alterations to the iron-catalyzed Fenton reaction. These interactions are particularly interesting in the context of bacterial infections. As iron is a vital nutrient for bacteria, modulating iron levels using the ECS may be able to control bacterial growth. This review aims to explore the current understanding of how the ECS affects iron homeostasis and its implications for bacterial pathogenesis. In this study, we provide an overview of both iron metabolism and the ECS, focusing on harnessing these systems to develop novel therapeutic strategies to modulate iron metabolism in bacterial infections. By elucidating these complex interactions, we hope to provide new insights into the development of novel treatments for bacterial infections.https://www.mdpi.com/2079-6382/14/6/614iron metabolismendocannabinoid systemhomeostasisiron chelation |
| spellingShingle | Kayle Brenna Dickson Juan Zhou Christian Lehmann Interactions Between Iron Metabolism and the Endocannabinoid System in Bacterial Infections Antibiotics iron metabolism endocannabinoid system homeostasis iron chelation |
| title | Interactions Between Iron Metabolism and the Endocannabinoid System in Bacterial Infections |
| title_full | Interactions Between Iron Metabolism and the Endocannabinoid System in Bacterial Infections |
| title_fullStr | Interactions Between Iron Metabolism and the Endocannabinoid System in Bacterial Infections |
| title_full_unstemmed | Interactions Between Iron Metabolism and the Endocannabinoid System in Bacterial Infections |
| title_short | Interactions Between Iron Metabolism and the Endocannabinoid System in Bacterial Infections |
| title_sort | interactions between iron metabolism and the endocannabinoid system in bacterial infections |
| topic | iron metabolism endocannabinoid system homeostasis iron chelation |
| url | https://www.mdpi.com/2079-6382/14/6/614 |
| work_keys_str_mv | AT kaylebrennadickson interactionsbetweenironmetabolismandtheendocannabinoidsysteminbacterialinfections AT juanzhou interactionsbetweenironmetabolismandtheendocannabinoidsysteminbacterialinfections AT christianlehmann interactionsbetweenironmetabolismandtheendocannabinoidsysteminbacterialinfections |