Photodynamic Therapy for Esophageal cancer
In photodynamic therapy, a photosensitizing drug is injected and then activated by light in the red spectral region to produce reactive, highly toxic singlet oxygen, which causes cell tissue and damage. When the distinction between tumoral and normal tissue is difficult at endoscopy, photodynamic th...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1990-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1990/586856 |
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| Summary: | In photodynamic therapy, a photosensitizing drug is injected and
then activated by light in the red spectral region to produce reactive, highly toxic
singlet oxygen, which causes cell tissue and damage. When the distinction
between tumoral and normal tissue is difficult at endoscopy, photodynamic
therapy is preferable to any other conservative method of destruction. The main
indications comprise genital, head and neck, bronchial, bladder and gastrointestinal
tumours, particularly esophageal cancer (including squamous cell cancer
and glandular neoplasia). Esophageal tumours should be class T1 or T2, at most,
and detected at endoscopy. Dysplasia which is flat, sessile and multicentric may
also be an indication for photodynamic therapy. Advanced esophageal cancers
are contraindicated for photodynamic therapy. |
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| ISSN: | 0835-7900 |