Development of a versatile chassis for the efficient production of diverse type II polyketides

Abstract Type II polyketides (T2PKs) exhibit a wide range of structural diversity and potent pharmacological activities. However, the optimal chassis for the synthesis of T2PKs remains elusive, impeding the effective mining and production of these compounds. In this study, we identify Streptomyces a...

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Bibliographic Details
Main Authors: Yang Zou, Ronghui Wang, Zhengjie Liu, Yuyang Zou, Shipeng Zeng, Min Fang, Hongmei Chen, Pengfei Wang, Changxian Xie, Zixin Deng, Fan Zhang, Ran Liu, Tiangang Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62659-0
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