Domain-specific AI segmentation of IMPDH2 rod/ring structures in mouse embryonic stem cells

Domain-specific AI segmentation of IMPDH2 rod/ring structures in mouse embryonic stem cells

Abstract Background Inosine monophosphate dehydrogenase 2 (IMPDH2) is an enzyme that catalyses the rate-limiting step of guanine nucleotides. In mouse embryonic stem cells (ESCs), IMPDH2 forms large multi-protein complexes known as rod-ring (RR) structures that dissociate when ESCs differentiate. Ma...

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Bibliographic Details
Main Authors: Samuel T. M. Ball, Meagan J. Hennessy, Yuhan Tan, Kai F. Hoettges, Neil D. Perkins, David J. Wilkinson, Michael R. H. White, Yalin Zheng, David A. Turner
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Biology
Subjects:
IMPDH2
Rods and rings
Loukoumasomes
Cytoophidia
Nematosomes
Embryonic stem cells
Online Access:https://doi.org/10.1186/s12915-025-02226-7
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