3,4-Dihydroxyphenylacetaldehyde synthase evolved an ordered structure to deliver oxygen to pyridoxal 5’-phosphate for cuticle assembly in the mosquito Aedes aegypti

3,4-Dihydroxyphenylacetaldehyde synthase evolved an ordered structure to deliver oxygen to pyridoxal 5’-phosphate for cuticle assembly in the mosquito Aedes aegypti

Abstract 3,4-Dihydroxyphenylacetaldehyde synthase (DHPAAS) catalyzes oxygen-dependent conversion of 3,4-dihydroxyphenylalanine (dopa) to 3,4-dihydroxyphenylacetaldehyde (DHPAA), a likely cross-linking agent precursor of the insect cuticle. In the current study, extensive in vivo experiments in Aedes...

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Main Authors: Jing Chen, Christopher J. Vavricka, Shuangshuang Wei, Yasumoto Nakazawa, Yuri Matsumoto, Huaqing Chen, Yu Tang, Jing Liang, Jiukai Chen, Yaneng Huang, Keiichi Noguchi, Tomohisa Hasunuma, Huai Guan, Jianyong Li, Chenghong Liao, Qian Han
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59723-0
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