Bone marrow sympathetic neuropathy is a hallmark of hematopoietic malignancies and it involves severe ultrastructural damage

Abstract The hematopoietic stem cell (HSC) niche in the bone marrow (BM) supports HSC function, fate and numbers [1]. Sympathetic fibres innervate the BM and are components of the hematopoietic stem and progenitor cell (HSPC) niche [2]. Neuropathy of the HSPC niche is present and essential for disea...

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Bibliographic Details
Main Authors:	Aurora Bernal, Vincent Cuminetti, Marc Serulla, Adrian Florit, Joanna Konieczny, Golnaz Golnarnik, Yimeng Chen, Marc Ferré, Samuel Geiseler, Anders Vik, Randi Olsen, Lorena Arranz
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Series:	Experimental Hematology & Oncology
Subjects:	Stem cell niche Hematological cancers Peripheral nervous system Sympathetic fibres Transmission electron microscopy
Online Access:	https://doi.org/10.1186/s40164-025-00614-x
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Bone marrow sympathetic neuropathy is a hallmark of hematopoietic malignancies and it involves severe ultrastructural damage

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