Bone marrow sympathetic neuropathy is a hallmark of hematopoietic malignancies and it involves severe ultrastructural damage

Bone marrow sympathetic neuropathy is a hallmark of hematopoietic malignancies and it involves severe ultrastructural damage

Abstract The hematopoietic stem cell (HSC) niche in the bone marrow (BM) supports HSC function, fate and numbers [1]. Sympathetic fibres innervate the BM and are components of the hematopoietic stem and progenitor cell (HSPC) niche [2]. Neuropathy of the HSPC niche is present and essential for disea...

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Bibliographic Details
Main Authors: Aurora Bernal, Vincent Cuminetti, Marc Serulla, Adrian Florit, Joanna Konieczny, Golnaz Golnarnik, Yimeng Chen, Marc Ferré, Samuel Geiseler, Anders Vik, Randi Olsen, Lorena Arranz
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Experimental Hematology & Oncology
Subjects:
Stem cell niche
Hematological cancers
Peripheral nervous system
Sympathetic fibres
Transmission electron microscopy
Online Access:https://doi.org/10.1186/s40164-025-00614-x
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