Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort study
Objective Previous research has shown that pulse pressure (PP) has a significant role in the start and development of type 2 diabetes mellitus. However, there is little proof that PP and pre-diabetes mellitus (Pre-DM) are related. Our study aimed to investigate the relationship between PP and incide...
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BMJ Publishing Group
2024-03-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/3/e080018.full |
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| author | Changchun Cao Haofei Hu Jiao Luo Yong Han Yongcheng He |
| author_facet | Changchun Cao Haofei Hu Jiao Luo Yong Han Yongcheng He |
| author_sort | Changchun Cao |
| collection | DOAJ |
| description | Objective Previous research has shown that pulse pressure (PP) has a significant role in the start and development of type 2 diabetes mellitus. However, there is little proof that PP and pre-diabetes mellitus (Pre-DM) are related. Our study aimed to investigate the relationship between PP and incident pre-DM in a substantial cohort of Chinese participants.Design The ‘DATADRYAD’ database (www.Datadryad.org) was used to retrieve the data for this secondary retrospective cohort analysis.Participants Data from 182 672 Chinese individuals who participated in the medical examination programme were recorded in this retrospective cohort study between 2010 and 2016 across 32 sites and 11 cities in China.Setting PP assessed at baseline and incident pre-DM during follow-up were the target-independent and dependent variables. The association between PP and pre-DM was investigated using Cox proportional hazards regression.Primary outcome measures The outcome was incident pre-DM. Impaired fasting glucose levels (fasting blood glucose between 5.6 and 6.9 mmol/L) were used to define pre-DM.Results After controlling for confounding variables, PP was positively correlated with incident pre-DM among Chinese adults (HR 1.009, 95% CI 1.007 to 1.010). Additionally, at a PP inflection point of 29 mm Hg, a non-linear connection between the PP and incident pre-DM was discovered. Increased PP was an independent risk factor for developing pre-DM when PP was greater than 29 mm Hg. However, their association was not significant when PP was less than 29 mm Hg. According to subgroup analyses, females, never-smokers and non-obesity correlated more significantly with PP and pre-DM.Conclusion We discovered that higher PP independently correlated with pre-DM risk in this study of Chinese participants. The connection between PP and incident pre-DM was also non-linear. High PP levels were related to a higher risk of pre-DM when PP was above 29 mm Hg.Article focus Our study investigated the relationship between PP and incident pre-DM in a secondary retrospective cohort of Chinese participants. |
| format | Article |
| id | doaj-art-7a76ccd80bfa4097af4e175b7aab337e |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-7a76ccd80bfa4097af4e175b7aab337e2025-08-20T03:11:38ZengBMJ Publishing GroupBMJ Open2044-60552024-03-0114310.1136/bmjopen-2023-080018Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort studyChangchun Cao0Haofei Hu1Jiao Luo2Yong Han3Yongcheng He4Department of Rehabilitation, Shenzhen Dapeng New District Nan’ao People’s Hospital, Shenzhen, Guangdong, ChinaDepartment of Nephrology, Shenzhen University First Affiliated Hospital, Shenzhen, Guangdong, ChinaDepartment of Rehabilitation, Shenzhen Dapeng New District Nan`ao People`s Hospital, Dapeng New District, Guangdong Province, ChinaDepartment of Emergency, Shenzhen Second People`s Hospital, Shenzhen, Guangdong Province, ChinaDepartment of Nephrology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, ChinaObjective Previous research has shown that pulse pressure (PP) has a significant role in the start and development of type 2 diabetes mellitus. However, there is little proof that PP and pre-diabetes mellitus (Pre-DM) are related. Our study aimed to investigate the relationship between PP and incident pre-DM in a substantial cohort of Chinese participants.Design The ‘DATADRYAD’ database (www.Datadryad.org) was used to retrieve the data for this secondary retrospective cohort analysis.Participants Data from 182 672 Chinese individuals who participated in the medical examination programme were recorded in this retrospective cohort study between 2010 and 2016 across 32 sites and 11 cities in China.Setting PP assessed at baseline and incident pre-DM during follow-up were the target-independent and dependent variables. The association between PP and pre-DM was investigated using Cox proportional hazards regression.Primary outcome measures The outcome was incident pre-DM. Impaired fasting glucose levels (fasting blood glucose between 5.6 and 6.9 mmol/L) were used to define pre-DM.Results After controlling for confounding variables, PP was positively correlated with incident pre-DM among Chinese adults (HR 1.009, 95% CI 1.007 to 1.010). Additionally, at a PP inflection point of 29 mm Hg, a non-linear connection between the PP and incident pre-DM was discovered. Increased PP was an independent risk factor for developing pre-DM when PP was greater than 29 mm Hg. However, their association was not significant when PP was less than 29 mm Hg. According to subgroup analyses, females, never-smokers and non-obesity correlated more significantly with PP and pre-DM.Conclusion We discovered that higher PP independently correlated with pre-DM risk in this study of Chinese participants. The connection between PP and incident pre-DM was also non-linear. High PP levels were related to a higher risk of pre-DM when PP was above 29 mm Hg.Article focus Our study investigated the relationship between PP and incident pre-DM in a secondary retrospective cohort of Chinese participants.https://bmjopen.bmj.com/content/14/3/e080018.full |
| spellingShingle | Changchun Cao Haofei Hu Jiao Luo Yong Han Yongcheng He Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort study BMJ Open |
| title | Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort study |
| title_full | Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort study |
| title_fullStr | Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort study |
| title_full_unstemmed | Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort study |
| title_short | Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort study |
| title_sort | non linear relationship between pulse pressure and the risk of pre diabetes a secondary retrospective chinese cohort study |
| url | https://bmjopen.bmj.com/content/14/3/e080018.full |
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