Quantitative adverse outcome pathway modeling for cigarette-smoke-induced airway mucus hypersecretion. Part 1: adverse-outcome-pathway-based in vitro assessment with repeated exposure to whole cigarette smoke

Quantitative adverse outcome pathway modeling for cigarette-smoke-induced airway mucus hypersecretion. Part 1: adverse-outcome-pathway-based in vitro assessment with repeated exposure to whole cigarette smoke

Adverse outcome pathway (AOP)-based chemical risk assessment is a promising tool for regulatory decision-making and is typically used in toxicological assessments. However, it also holds potential for pharmacological and disease-related evaluations. The present study focuses on an AOP for decreased...

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Bibliographic Details
Main Authors: Sakuya Ichikawa, Shugo Muratani, Keigo Sano, Kazuo Erami, Akina Mori, Risa Matsumoto, Shigeaki Ito
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Toxicology
Subjects:
in vitro disease modeling
repeated exposure
chronic bronchitis
smoke inhalation
new approach methodology
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2025.1564857/full
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