Sensitive and modular amplicon sequencing of Plasmodium falciparum diversity and resistance for research and public health

Sensitive and modular amplicon sequencing of Plasmodium falciparum diversity and resistance for research and public health

Abstract Targeted amplicon sequencing is a powerful and efficient tool for interrogating the Plasmodium falciparum genome, generating actionable data from infections to complement traditional malaria epidemiology. For maximum impact, genomic tools should be multi-purpose, robust, sensitive, and repr...

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Main Authors: Andrés Aranda-Díaz, Eric Neubauer Vickers, Kathryn Murie, Brian Palmer, Nicholas Hathaway, Inna Gerlovina, Simone Boene, Manuel García-Ulloa, Pau Cisteró, Thomas Katairo, Francis Ddumba Semakuba, Bienvenu Nsengimaana, Hazel Gwarinda, Carla García-Fernández, William Louie, Endashaw Esayas, Clemente Da Silva, Debayan Datta, Shahiid Kiyaga, Innocent Wiringilimaana, Sindew Mekasha Feleke, Adam Bennett, Jennifer L. Smith, Endalamaw Gadisa, Jonathan B. Parr, Melissa D. Conrad, Jaishree Raman, Stephen Tukwasibwe, Isaac Ssewanyana, Eduard Rovira-Vallbona, Cristina M. Tato, Jessica Briggs, Alfredo Mayor, Bryan Greenhouse
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Malaria
Plasmodium falciparum
Targeted amplicon sequencing
Microhaplotype
Antimalarial resistance
Online Access:https://doi.org/10.1038/s41598-025-94716-5
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