Sputum immunoglobulin E levels correlate with eosinophilic airway regardless of atopy
Abstract Immunoglobulin E (IgE) is a key molecule that induces mast cell activation in allergic inflammation and contributes to type 2/eosinophilic inflammation in asthmatic airways. This cross-sectional study investigated the role of local IgE in asthmatic airways according to atopy, asthma control...
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BMC
2025-06-01
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| Series: | Allergy, Asthma & Clinical Immunology |
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| Online Access: | https://doi.org/10.1186/s13223-025-00976-1 |
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| author | Hyo-In Rhyou Thi Bich Tra Cao Quang Luu Quoc Young-Hee Nam Hae-Sim Park |
| author_facet | Hyo-In Rhyou Thi Bich Tra Cao Quang Luu Quoc Young-Hee Nam Hae-Sim Park |
| author_sort | Hyo-In Rhyou |
| collection | DOAJ |
| description | Abstract Immunoglobulin E (IgE) is a key molecule that induces mast cell activation in allergic inflammation and contributes to type 2/eosinophilic inflammation in asthmatic airways. This cross-sectional study investigated the role of local IgE in asthmatic airways according to atopy, asthma control, and eosinophilic inflammation. A total of 31 adult patients with moderate-to-severe asthma were enrolled. The study subjects were classified into (1) atopic/non-atopic, (2) controlled/partly controlled/uncontrolled asthma and (3) eosinophilic/non-eosinophilic asthma. Serum/sputum IgE and serum/urine eosinophil-derived neurotoxin (EDN) were measured. Serum IgE levels were higher in atopic asthmatics than in non-atopic asthmatics, whereas no differences were noted in sputum IgE levels. Sputum IgE levels were significantly higher in uncontrolled asthmatics than in partly controlled or controlled asthmatics, and in eosinophilic asthmatics than in non-eosinophilic asthmatics, whereas no differences were noted in serum IgE levels. Significant correlations were observed between serum EDN and serum/sputum IgE levels. The production of local IgE in asthmatic airways could contribute to type 2/eosinophilic inflammation, irrespective of atopy, resulting in poor asthma control. Strategies targeting IgE may be effective in the management of non-atopic and atopic asthma. |
| format | Article |
| id | doaj-art-7a733f1b5eae458584b6ffda1579d75a |
| institution | DOAJ |
| issn | 1710-1492 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
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| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj-art-7a733f1b5eae458584b6ffda1579d75a2025-08-20T03:03:33ZengBMCAllergy, Asthma & Clinical Immunology1710-14922025-06-012111410.1186/s13223-025-00976-1Sputum immunoglobulin E levels correlate with eosinophilic airway regardless of atopyHyo-In Rhyou0Thi Bich Tra Cao1Quang Luu Quoc2Young-Hee Nam3Hae-Sim Park4Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of MedicineDepartment of Allergy and Clinical Immunology, Ajou University School of MedicineDepartment of Allergy and Clinical Immunology, Ajou University School of MedicineDepartment of Internal Medicine, College of Medicine, Dong-A University, Dong-A University HospitalDepartment of Allergy and Clinical Immunology, Ajou University School of MedicineAbstract Immunoglobulin E (IgE) is a key molecule that induces mast cell activation in allergic inflammation and contributes to type 2/eosinophilic inflammation in asthmatic airways. This cross-sectional study investigated the role of local IgE in asthmatic airways according to atopy, asthma control, and eosinophilic inflammation. A total of 31 adult patients with moderate-to-severe asthma were enrolled. The study subjects were classified into (1) atopic/non-atopic, (2) controlled/partly controlled/uncontrolled asthma and (3) eosinophilic/non-eosinophilic asthma. Serum/sputum IgE and serum/urine eosinophil-derived neurotoxin (EDN) were measured. Serum IgE levels were higher in atopic asthmatics than in non-atopic asthmatics, whereas no differences were noted in sputum IgE levels. Sputum IgE levels were significantly higher in uncontrolled asthmatics than in partly controlled or controlled asthmatics, and in eosinophilic asthmatics than in non-eosinophilic asthmatics, whereas no differences were noted in serum IgE levels. Significant correlations were observed between serum EDN and serum/sputum IgE levels. The production of local IgE in asthmatic airways could contribute to type 2/eosinophilic inflammation, irrespective of atopy, resulting in poor asthma control. Strategies targeting IgE may be effective in the management of non-atopic and atopic asthma.https://doi.org/10.1186/s13223-025-00976-1AsthmaAtopyImmunoglobulin EEosinophilSputumSerum |
| spellingShingle | Hyo-In Rhyou Thi Bich Tra Cao Quang Luu Quoc Young-Hee Nam Hae-Sim Park Sputum immunoglobulin E levels correlate with eosinophilic airway regardless of atopy Allergy, Asthma & Clinical Immunology Asthma Atopy Immunoglobulin E Eosinophil Sputum Serum |
| title | Sputum immunoglobulin E levels correlate with eosinophilic airway regardless of atopy |
| title_full | Sputum immunoglobulin E levels correlate with eosinophilic airway regardless of atopy |
| title_fullStr | Sputum immunoglobulin E levels correlate with eosinophilic airway regardless of atopy |
| title_full_unstemmed | Sputum immunoglobulin E levels correlate with eosinophilic airway regardless of atopy |
| title_short | Sputum immunoglobulin E levels correlate with eosinophilic airway regardless of atopy |
| title_sort | sputum immunoglobulin e levels correlate with eosinophilic airway regardless of atopy |
| topic | Asthma Atopy Immunoglobulin E Eosinophil Sputum Serum |
| url | https://doi.org/10.1186/s13223-025-00976-1 |
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