Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization
Adipose-derived mesenchymal stem cells (ADSCs) exhibit superior immunomodulatory properties and have broad therapeutic applications. They induce macrophage M2 polarization for anti-inflammatory responses. Exosomes derived from ADSCs (ADSC-EXOs) exhibit biological functions similar to those of ADSCs...
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| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1525466/full |
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| author | Zhewei Dong Yingli Fu Zhongming Cai Hao Dai Yucang He |
| author_facet | Zhewei Dong Yingli Fu Zhongming Cai Hao Dai Yucang He |
| author_sort | Zhewei Dong |
| collection | DOAJ |
| description | Adipose-derived mesenchymal stem cells (ADSCs) exhibit superior immunomodulatory properties and have broad therapeutic applications. They induce macrophage M2 polarization for anti-inflammatory responses. Exosomes derived from ADSCs (ADSC-EXOs) exhibit biological functions similar to those of ADSCs but can circumvent the limitations associated with cellular injection therapies. Potent anti-inflammatory substances contained in exosomes include the glycoprotein MFGE8, the cytokines such as prostaglandin E2, IL-6, and IGF, as well as non-coding nucleotides (miR-451a, miR-23, miR-30d-5p, let-7, lncRNA DLEU2, circRps5, Circ-Ptpn4, and mmu_ circ_0001359). The anti-inflammatory and immunomodulatory properties of these exosomes provide new perspectives for therapeutic approaches for graft inflammation, bone healing, acute lung injury, kidney stones, myocardial infarction, and diabetes-related diseases. This review summarizes the contents and functions of ADSC-EXOs, outlines their properties and the characteristics of macrophage phenotypes, and emphasizes their impact on macrophage polarization and their contribution to immune-related diseases. |
| format | Article |
| id | doaj-art-7a728ed1694241a084d7c64b68edfae1 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-7a728ed1694241a084d7c64b68edfae12025-02-03T05:12:05ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15254661525466Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarizationZhewei Dong0Yingli Fu1Zhongming Cai2Hao Dai3Yucang He4Renji College, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Plastic Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Breast Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Plastic Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Plastic Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaAdipose-derived mesenchymal stem cells (ADSCs) exhibit superior immunomodulatory properties and have broad therapeutic applications. They induce macrophage M2 polarization for anti-inflammatory responses. Exosomes derived from ADSCs (ADSC-EXOs) exhibit biological functions similar to those of ADSCs but can circumvent the limitations associated with cellular injection therapies. Potent anti-inflammatory substances contained in exosomes include the glycoprotein MFGE8, the cytokines such as prostaglandin E2, IL-6, and IGF, as well as non-coding nucleotides (miR-451a, miR-23, miR-30d-5p, let-7, lncRNA DLEU2, circRps5, Circ-Ptpn4, and mmu_ circ_0001359). The anti-inflammatory and immunomodulatory properties of these exosomes provide new perspectives for therapeutic approaches for graft inflammation, bone healing, acute lung injury, kidney stones, myocardial infarction, and diabetes-related diseases. This review summarizes the contents and functions of ADSC-EXOs, outlines their properties and the characteristics of macrophage phenotypes, and emphasizes their impact on macrophage polarization and their contribution to immune-related diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1525466/fullexosomesadipose-derived mesenchymal stem cellsmacrophage polarizationM2 macrophagesinflammatory diseases |
| spellingShingle | Zhewei Dong Yingli Fu Zhongming Cai Hao Dai Yucang He Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization Frontiers in Immunology exosomes adipose-derived mesenchymal stem cells macrophage polarization M2 macrophages inflammatory diseases |
| title | Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization |
| title_full | Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization |
| title_fullStr | Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization |
| title_full_unstemmed | Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization |
| title_short | Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization |
| title_sort | recent advances in adipose derived mesenchymal stem cell derived exosomes for regulating macrophage polarization |
| topic | exosomes adipose-derived mesenchymal stem cells macrophage polarization M2 macrophages inflammatory diseases |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1525466/full |
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