Anemia during pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis of cohort studies
ObjectivesAnemia in pregnancy has been a topic of interest for researchers due to its potential impact on various adverse pregnancy outcomes. This study aims to explore the relationship between anemia and adverse pregnancy outcomes such as preterm birth, low birth weight, and maternal mortality.Meth...
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| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Global Women's Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgwh.2025.1502585/full |
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| author | Rui Wang Shan Xu Xiaoyu Hao Xingyi Jin Da Pan Hui Xia Wang Liao Ligang Yang Shaokang Wang Shaokang Wang |
| author_facet | Rui Wang Shan Xu Xiaoyu Hao Xingyi Jin Da Pan Hui Xia Wang Liao Ligang Yang Shaokang Wang Shaokang Wang |
| author_sort | Rui Wang |
| collection | DOAJ |
| description | ObjectivesAnemia in pregnancy has been a topic of interest for researchers due to its potential impact on various adverse pregnancy outcomes. This study aims to explore the relationship between anemia and adverse pregnancy outcomes such as preterm birth, low birth weight, and maternal mortality.MethodsWe conducted both a systematic review and a meta-analysis on the associations between anemia during pregnancy and adverse pregnancy outcomes. We searched Chinese databases (CNKI, Wanfang, CBM, VIP) and English ones (Cochrane Library, PubMed, Embase, Web of Science). Two researcher-authors independently assessed study quality with the Newcastle-Ottawa Scale. After extracting data, we analyzed heterogeneity and used a random-effects model for higher heterogeneity and a fixed-effects model for low heterogeneity in the meta-analysis while also systematically synthesizing and narratively describing findings in the systematic review.ResultsA total of 31 cohort studies were included. Meta-analysis showed that the risk of postpartum hemorrhage [RR [95% CI], 2.76 [1.63, 4.66]], premature rupture of membranes (PROM) [1.94 (1.26, 3.00)], preterm delivery [1.51 (1.33, 1.72)], low birth weight (LBW) [1.40 (1.19, 1.63)], cesarean section[1.33 (1.02, 1.74)], gestational hypertension[1.28 (1.14, 1.44)] and neonatal asphyxia[1.21 (1.07, 1.37)] was higher in the group of anemia in pregnancy than in the control group.ConclusionMaternal anemia is associated with an increased risk of seven adverse pregnancy outcomes: postpartum hemorrhage, PROM, preterm delivery, LBW, cesarean section, gestational hypertension and neonatal asphyxia. Appropriate nutritional supplementation and screening for anemia before and during pregnancy are recommended to improve maternal health and manage adverse pregnancy outcomes. |
| format | Article |
| id | doaj-art-7a708c293fc443dc80d387a1e66ab050 |
| institution | Kabale University |
| issn | 2673-5059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Global Women's Health |
| spelling | doaj-art-7a708c293fc443dc80d387a1e66ab0502025-01-31T06:40:21ZengFrontiers Media S.A.Frontiers in Global Women's Health2673-50592025-01-01610.3389/fgwh.2025.15025851502585Anemia during pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis of cohort studiesRui Wang0Shan Xu1Xiaoyu Hao2Xingyi Jin3Da Pan4Hui Xia5Wang Liao6Ligang Yang7Shaokang Wang8Shaokang Wang9Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, ChinaClinical Medical Research Center for Plateau Gastroenterological Disease of Xizang Autonomous Region, and School of Medicine, Xizang Minzu University, Xianyang, ChinaObjectivesAnemia in pregnancy has been a topic of interest for researchers due to its potential impact on various adverse pregnancy outcomes. This study aims to explore the relationship between anemia and adverse pregnancy outcomes such as preterm birth, low birth weight, and maternal mortality.MethodsWe conducted both a systematic review and a meta-analysis on the associations between anemia during pregnancy and adverse pregnancy outcomes. We searched Chinese databases (CNKI, Wanfang, CBM, VIP) and English ones (Cochrane Library, PubMed, Embase, Web of Science). Two researcher-authors independently assessed study quality with the Newcastle-Ottawa Scale. After extracting data, we analyzed heterogeneity and used a random-effects model for higher heterogeneity and a fixed-effects model for low heterogeneity in the meta-analysis while also systematically synthesizing and narratively describing findings in the systematic review.ResultsA total of 31 cohort studies were included. Meta-analysis showed that the risk of postpartum hemorrhage [RR [95% CI], 2.76 [1.63, 4.66]], premature rupture of membranes (PROM) [1.94 (1.26, 3.00)], preterm delivery [1.51 (1.33, 1.72)], low birth weight (LBW) [1.40 (1.19, 1.63)], cesarean section[1.33 (1.02, 1.74)], gestational hypertension[1.28 (1.14, 1.44)] and neonatal asphyxia[1.21 (1.07, 1.37)] was higher in the group of anemia in pregnancy than in the control group.ConclusionMaternal anemia is associated with an increased risk of seven adverse pregnancy outcomes: postpartum hemorrhage, PROM, preterm delivery, LBW, cesarean section, gestational hypertension and neonatal asphyxia. Appropriate nutritional supplementation and screening for anemia before and during pregnancy are recommended to improve maternal health and manage adverse pregnancy outcomes.https://www.frontiersin.org/articles/10.3389/fgwh.2025.1502585/fullanemiaanemia in pregnancypregnancy outcomecohort studymaternal health |
| spellingShingle | Rui Wang Shan Xu Xiaoyu Hao Xingyi Jin Da Pan Hui Xia Wang Liao Ligang Yang Shaokang Wang Shaokang Wang Anemia during pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis of cohort studies Frontiers in Global Women's Health anemia anemia in pregnancy pregnancy outcome cohort study maternal health |
| title | Anemia during pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis of cohort studies |
| title_full | Anemia during pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis of cohort studies |
| title_fullStr | Anemia during pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis of cohort studies |
| title_full_unstemmed | Anemia during pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis of cohort studies |
| title_short | Anemia during pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis of cohort studies |
| title_sort | anemia during pregnancy and adverse pregnancy outcomes a systematic review and meta analysis of cohort studies |
| topic | anemia anemia in pregnancy pregnancy outcome cohort study maternal health |
| url | https://www.frontiersin.org/articles/10.3389/fgwh.2025.1502585/full |
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