Recent Advances in Amyloids Structural Studies and Thin Film Applications
Amyloids are protein-based biomaterials composed of fibrils with cross-β cores. Previously only associated with degenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, and diabetes, amyloids remain active and functional both in vivo and in vitro conditions, enabling a variety of app...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/14/2908 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850072168579203072 |
|---|---|
| author | Eugenia Pechkova Stefano Fiordoro Alberto Izzotti Christian Riekel |
| author_facet | Eugenia Pechkova Stefano Fiordoro Alberto Izzotti Christian Riekel |
| author_sort | Eugenia Pechkova |
| collection | DOAJ |
| description | Amyloids are protein-based biomaterials composed of fibrils with cross-β cores. Previously only associated with degenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, and diabetes, amyloids remain active and functional both in vivo and in vitro conditions, enabling a variety of applications in medicine, nanotechnology, and biotechnology. This review aims to review the most advanced methods for amyloid fibril structural studies, with special attention on amyloid thin films. Selected advances of biomedical and biotechnological relevance will be outlined, and perspectives for future studies in the context of ongoing methodological progress will be discussed. |
| format | Article |
| id | doaj-art-7a6ee605ee3647b7aefce5cdbb9907a7 |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-7a6ee605ee3647b7aefce5cdbb9907a72025-08-20T02:47:07ZengMDPI AGMolecules1420-30492025-07-013014290810.3390/molecules30142908Recent Advances in Amyloids Structural Studies and Thin Film ApplicationsEugenia Pechkova0Stefano Fiordoro1Alberto Izzotti2Christian Riekel3Laboratories of Biophysics and Nanotechnology, Department of Experimental Medicine (DIMES), University of Genova Medical School, Via A. Pastore, 3, 16132 Genova, ItalyDepartment of Health Science (DISSAL), University of Genova Medical School, 16132 Genova, ItalyDepartment of Experimental Medicine (DIMES), University of Genova Medical School, 16132 Genova, ItalyEuropean Synchrotron Radiation Facility, CS40220, F-38043 Grenoble Cedex 9, FranceAmyloids are protein-based biomaterials composed of fibrils with cross-β cores. Previously only associated with degenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, and diabetes, amyloids remain active and functional both in vivo and in vitro conditions, enabling a variety of applications in medicine, nanotechnology, and biotechnology. This review aims to review the most advanced methods for amyloid fibril structural studies, with special attention on amyloid thin films. Selected advances of biomedical and biotechnological relevance will be outlined, and perspectives for future studies in the context of ongoing methodological progress will be discussed.https://www.mdpi.com/1420-3049/30/14/2908amyloid fibrilsamyloid thin filmhigh brilliance X-ray diffractioncryo-electron microscopy |
| spellingShingle | Eugenia Pechkova Stefano Fiordoro Alberto Izzotti Christian Riekel Recent Advances in Amyloids Structural Studies and Thin Film Applications Molecules amyloid fibrils amyloid thin film high brilliance X-ray diffraction cryo-electron microscopy |
| title | Recent Advances in Amyloids Structural Studies and Thin Film Applications |
| title_full | Recent Advances in Amyloids Structural Studies and Thin Film Applications |
| title_fullStr | Recent Advances in Amyloids Structural Studies and Thin Film Applications |
| title_full_unstemmed | Recent Advances in Amyloids Structural Studies and Thin Film Applications |
| title_short | Recent Advances in Amyloids Structural Studies and Thin Film Applications |
| title_sort | recent advances in amyloids structural studies and thin film applications |
| topic | amyloid fibrils amyloid thin film high brilliance X-ray diffraction cryo-electron microscopy |
| url | https://www.mdpi.com/1420-3049/30/14/2908 |
| work_keys_str_mv | AT eugeniapechkova recentadvancesinamyloidsstructuralstudiesandthinfilmapplications AT stefanofiordoro recentadvancesinamyloidsstructuralstudiesandthinfilmapplications AT albertoizzotti recentadvancesinamyloidsstructuralstudiesandthinfilmapplications AT christianriekel recentadvancesinamyloidsstructuralstudiesandthinfilmapplications |