Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility.

Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility.

While most chemokine receptors fail to cross the chemokine class boundary with respect to the ligands that they bind, the human cytomegalovirus (HCMV)-encoded chemokine receptor US28 binds multiple CC-chemokines and the CX(3)C-chemokine Fractalkine. US28 binding to CC-chemokines is both necessary an...

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Bibliographic Details
Main Authors: Jennifer Vomaske, Ryan M Melnychuk, Patricia P Smith, Joshua Powell, Laurel Hall, Victor DeFilippis, Klaus Früh, Martine Smit, David D Schlaepfer, Jay A Nelson, Daniel N Streblow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-02-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000304&type=printable
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