Stability of Ceftiofur Sodium and Cefquinome Sulphate in Intravenous Solutions
Stability of ceftiofur sodium and cefquinome sulphate in intravenous solutions was studied. Chromatographic separation and quantitative determination were performed by using a high-performance liquid chromatography with UV-DAD detection. During the stability study, poly(vinylchloride) minibags were...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/583461 |
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| author | Agnieszka Dołhań Anna Jelińska Marcelina Bębenek |
| author_facet | Agnieszka Dołhań Anna Jelińska Marcelina Bębenek |
| author_sort | Agnieszka Dołhań |
| collection | DOAJ |
| description | Stability of ceftiofur sodium and cefquinome sulphate in intravenous solutions was studied. Chromatographic separation and quantitative determination were performed by using a high-performance liquid chromatography with UV-DAD detection. During the stability study, poly(vinylchloride) minibags were filled with a solution containing 5 mg of ceftiofur sodium or cefquinome sulphate and diluted to 0.2 mg/mL with suitable intravenous solution depending on the test conditions. The solutions for the study were protected from light and stored at room temperature (22°C), refrigerated (6°C), frozen (−20°C) for 30 days, and then thawed at room temperature. A comparison of results obtained at 22°C and 6°C for the same intravenous solutions showed that temperature as well as components of solutions and their concentration had an influence on the stability of ceftiofur sodium and cefquinome sulphate. It was found that ceftiofur sodium and cefquinome sulphate dissolved in intravenous solutions used in this study may be stored at room temperature and at 6°C for up to 48 h. |
| format | Article |
| id | doaj-art-7a6c240656b14712ad118db557e45286 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7a6c240656b14712ad118db557e452862025-02-03T01:31:27ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/583461583461Stability of Ceftiofur Sodium and Cefquinome Sulphate in Intravenous SolutionsAgnieszka Dołhań0Anna Jelińska1Marcelina Bębenek2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, PolandDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, PolandDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, PolandStability of ceftiofur sodium and cefquinome sulphate in intravenous solutions was studied. Chromatographic separation and quantitative determination were performed by using a high-performance liquid chromatography with UV-DAD detection. During the stability study, poly(vinylchloride) minibags were filled with a solution containing 5 mg of ceftiofur sodium or cefquinome sulphate and diluted to 0.2 mg/mL with suitable intravenous solution depending on the test conditions. The solutions for the study were protected from light and stored at room temperature (22°C), refrigerated (6°C), frozen (−20°C) for 30 days, and then thawed at room temperature. A comparison of results obtained at 22°C and 6°C for the same intravenous solutions showed that temperature as well as components of solutions and their concentration had an influence on the stability of ceftiofur sodium and cefquinome sulphate. It was found that ceftiofur sodium and cefquinome sulphate dissolved in intravenous solutions used in this study may be stored at room temperature and at 6°C for up to 48 h.http://dx.doi.org/10.1155/2014/583461 |
| spellingShingle | Agnieszka Dołhań Anna Jelińska Marcelina Bębenek Stability of Ceftiofur Sodium and Cefquinome Sulphate in Intravenous Solutions The Scientific World Journal |
| title | Stability of Ceftiofur Sodium and Cefquinome Sulphate in Intravenous Solutions |
| title_full | Stability of Ceftiofur Sodium and Cefquinome Sulphate in Intravenous Solutions |
| title_fullStr | Stability of Ceftiofur Sodium and Cefquinome Sulphate in Intravenous Solutions |
| title_full_unstemmed | Stability of Ceftiofur Sodium and Cefquinome Sulphate in Intravenous Solutions |
| title_short | Stability of Ceftiofur Sodium and Cefquinome Sulphate in Intravenous Solutions |
| title_sort | stability of ceftiofur sodium and cefquinome sulphate in intravenous solutions |
| url | http://dx.doi.org/10.1155/2014/583461 |
| work_keys_str_mv | AT agnieszkadołhan stabilityofceftiofursodiumandcefquinomesulphateinintravenoussolutions AT annajelinska stabilityofceftiofursodiumandcefquinomesulphateinintravenoussolutions AT marcelinabebenek stabilityofceftiofursodiumandcefquinomesulphateinintravenoussolutions |