Chronic kidney disease and inflammatory cytokines in rheumatoid arthritis: a potential pathogenic link
Recent evidence indicates an increased risk of chronic kidney disease (CKD) in patients with rheumatoid arthritis (RA), with prevalence rates ranging from 20.8% to 24.5%. Risk factors for CKD among RA patients include advancing age, diabetes, cardiovascular disease, hypertension and RA disease activ...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-01-01
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| Series: | Immunological Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/25785826.2025.2460267 |
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| author | Hironari Hanaoka Takumi Aoki Taiji Kosaka Shoichi Yoshinaga Akiko Shibata Ryota Sakai Takahiko Kurasawa Koichi Amano |
| author_facet | Hironari Hanaoka Takumi Aoki Taiji Kosaka Shoichi Yoshinaga Akiko Shibata Ryota Sakai Takahiko Kurasawa Koichi Amano |
| author_sort | Hironari Hanaoka |
| collection | DOAJ |
| description | Recent evidence indicates an increased risk of chronic kidney disease (CKD) in patients with rheumatoid arthritis (RA), with prevalence rates ranging from 20.8% to 24.5%. Risk factors for CKD among RA patients include advancing age, diabetes, cardiovascular disease, hypertension and RA disease activity. Medications such as glucocorticoids and nonsteroidal anti-inflammatory drugs (NSAIDs) may also accelerate CKD progression. Inflammatory cytokines, notably interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and IL-1, play significant roles in the pathogenesis of both RA and CKD, promoting systemic inflammation and renal impairment. Elevated levels of various cytokines have been detected in the plasma and urine of CKD patients, and they raise morbidity and mortality rates, even during early disease stages. Effective management of RA activity and modifications in treatment to reduce renal burden are essential for lowering CKD risk and improving patient outcomes. Biological disease-modifying antirheumatic drugs (DMARDs), particularly those targeting IL-6 and TNF-α, show potential in mitigating CKD progression in RA patients. However, individualized treatment and careful kidney function monitoring are critical, as CKD may impact RA management. Future research should focus on therapeutic strategies that address inflammation in both RA and CKD to optimize patient care. |
| format | Article |
| id | doaj-art-7a6bc3bcb2f54d5b93600b1ad6941b3c |
| institution | Kabale University |
| issn | 2578-5826 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Immunological Medicine |
| spelling | doaj-art-7a6bc3bcb2f54d5b93600b1ad6941b3c2025-01-31T12:29:33ZengTaylor & Francis GroupImmunological Medicine2578-58262025-01-0111010.1080/25785826.2025.2460267Chronic kidney disease and inflammatory cytokines in rheumatoid arthritis: a potential pathogenic linkHironari Hanaoka0Takumi Aoki1Taiji Kosaka2Shoichi Yoshinaga3Akiko Shibata4Ryota Sakai5Takahiko Kurasawa6Koichi Amano7Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, JapanDepartment of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, JapanDepartment of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, JapanDepartment of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, JapanDepartment of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, JapanDepartment of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, JapanDepartment of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, JapanDepartment of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, JapanRecent evidence indicates an increased risk of chronic kidney disease (CKD) in patients with rheumatoid arthritis (RA), with prevalence rates ranging from 20.8% to 24.5%. Risk factors for CKD among RA patients include advancing age, diabetes, cardiovascular disease, hypertension and RA disease activity. Medications such as glucocorticoids and nonsteroidal anti-inflammatory drugs (NSAIDs) may also accelerate CKD progression. Inflammatory cytokines, notably interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and IL-1, play significant roles in the pathogenesis of both RA and CKD, promoting systemic inflammation and renal impairment. Elevated levels of various cytokines have been detected in the plasma and urine of CKD patients, and they raise morbidity and mortality rates, even during early disease stages. Effective management of RA activity and modifications in treatment to reduce renal burden are essential for lowering CKD risk and improving patient outcomes. Biological disease-modifying antirheumatic drugs (DMARDs), particularly those targeting IL-6 and TNF-α, show potential in mitigating CKD progression in RA patients. However, individualized treatment and careful kidney function monitoring are critical, as CKD may impact RA management. Future research should focus on therapeutic strategies that address inflammation in both RA and CKD to optimize patient care.https://www.tandfonline.com/doi/10.1080/25785826.2025.2460267Chronic kidney diseaserheumatoid arthritisinflammatory cytokinesinterleukin-6 |
| spellingShingle | Hironari Hanaoka Takumi Aoki Taiji Kosaka Shoichi Yoshinaga Akiko Shibata Ryota Sakai Takahiko Kurasawa Koichi Amano Chronic kidney disease and inflammatory cytokines in rheumatoid arthritis: a potential pathogenic link Immunological Medicine Chronic kidney disease rheumatoid arthritis inflammatory cytokines interleukin-6 |
| title | Chronic kidney disease and inflammatory cytokines in rheumatoid arthritis: a potential pathogenic link |
| title_full | Chronic kidney disease and inflammatory cytokines in rheumatoid arthritis: a potential pathogenic link |
| title_fullStr | Chronic kidney disease and inflammatory cytokines in rheumatoid arthritis: a potential pathogenic link |
| title_full_unstemmed | Chronic kidney disease and inflammatory cytokines in rheumatoid arthritis: a potential pathogenic link |
| title_short | Chronic kidney disease and inflammatory cytokines in rheumatoid arthritis: a potential pathogenic link |
| title_sort | chronic kidney disease and inflammatory cytokines in rheumatoid arthritis a potential pathogenic link |
| topic | Chronic kidney disease rheumatoid arthritis inflammatory cytokines interleukin-6 |
| url | https://www.tandfonline.com/doi/10.1080/25785826.2025.2460267 |
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