The role of KLF4 in human primordial germ cell development

The role of KLF4 in human primordial germ cell development

Primordial germ cells (PGCs) are the founder cells that develop into mature gametes. PGCs emerge during weeks 2–3 of human embryo development. Pluripotency genes are reactivated during PGC specification, including Krüppel-like factor KLF4, but its precise role in PGC development is unclear. Here, we...

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Bibliographic Details
Main Authors: Sun-Min Lee, Merrick Pierson Smela, M. Azim Surani
Format: Article
Language:English
Published: The Royal Society 2025-01-01
Series:Open Biology
Subjects:
KLF4
primordial germ cells
stem cells
pluripotency factors
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.240214
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