Pre-diabetes and cardiovascular risk factors in NAFLD patients: a retrospective comparative analysis
ObjectivesInsulin resistance plays a critical role in the pathophysiology of diabetes mellitus and non-alcoholic fatty liver disease (NAFLD). Moreover, insulin resistance has a central role in atherogensis as the major leading cause of cardiovascular disease (CVD). The aim of the present study was t...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1416407/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206795207966720 |
|---|---|
| author | Azam Teimouri Zahra Ebrahimpour Awat Feizi Bijan Iraj Elahe Saffari Mojtaba Akbari Mozhgan Karimifar |
| author_facet | Azam Teimouri Zahra Ebrahimpour Awat Feizi Bijan Iraj Elahe Saffari Mojtaba Akbari Mozhgan Karimifar |
| author_sort | Azam Teimouri |
| collection | DOAJ |
| description | ObjectivesInsulin resistance plays a critical role in the pathophysiology of diabetes mellitus and non-alcoholic fatty liver disease (NAFLD). Moreover, insulin resistance has a central role in atherogensis as the major leading cause of cardiovascular disease (CVD). The aim of the present study was to assess the frequency of pre-diabetes and evaluate the cardiometabolic risk factors among NAFLD patients, comparing those with pre-diabetes to those with normal glucose tolerance.MethodsIn the current retrospective case-control study, the data of 1031 NAFLD patients was retrieved. Based on blood glucose levels, 337 diabetics, 340 pre-diabetes, and, 354 normal glucose patients were diagnosed. After excluding diabetic NAFLD patients, 694 individuals were divided into two groups: normal glucose and pre-diabetes. Various variables, such as age, anthropometric measurements, hypertension, systolic and diastolic blood pressure, and lipid profiles, were extracted from patient files. Statistical analysis was conducted to assess cardiovascular risk factors in NAFLD patients.ResultsHigher age, female gender, higher BMI, triglyceride, waist and hip circumference and waist-to-hip ratio were found in pre-diabetic NAFLD individuals compared with normoglycemic ones (P-value<0.05). Multivariable age-, sex-, BMI- and smoking- adjusted logistic regression showed a predicting role of pre-diabetes and NAFLD concurrence with metabolic syndrome (P-value<0.001, OR:4.31, 95% CI: 2.95- 6.29), but not CVD (P-value=0.353, OR:1.37, 95% CI: 0.71- 2.61).ConclusionIn this study, nearly one-third of NAFLD patients had pre-diabetes. The mean value of age, BMI, TG, waist and Hip circumference was significantly higher in pre-diabetic patients. The concurrence of pre-diabetes and NAFLD was a predicting factor for metabolic syndrome, but not CVD events. |
| format | Article |
| id | doaj-art-7a61457005444571b8f44a5ccfa678c6 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-7a61457005444571b8f44a5ccfa678c62025-02-07T05:10:32ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.14164071416407Pre-diabetes and cardiovascular risk factors in NAFLD patients: a retrospective comparative analysisAzam Teimouri0Zahra Ebrahimpour1Awat Feizi2Bijan Iraj3Elahe Saffari4Mojtaba Akbari5Mozhgan Karimifar6Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, IranMetabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, IranObjectivesInsulin resistance plays a critical role in the pathophysiology of diabetes mellitus and non-alcoholic fatty liver disease (NAFLD). Moreover, insulin resistance has a central role in atherogensis as the major leading cause of cardiovascular disease (CVD). The aim of the present study was to assess the frequency of pre-diabetes and evaluate the cardiometabolic risk factors among NAFLD patients, comparing those with pre-diabetes to those with normal glucose tolerance.MethodsIn the current retrospective case-control study, the data of 1031 NAFLD patients was retrieved. Based on blood glucose levels, 337 diabetics, 340 pre-diabetes, and, 354 normal glucose patients were diagnosed. After excluding diabetic NAFLD patients, 694 individuals were divided into two groups: normal glucose and pre-diabetes. Various variables, such as age, anthropometric measurements, hypertension, systolic and diastolic blood pressure, and lipid profiles, were extracted from patient files. Statistical analysis was conducted to assess cardiovascular risk factors in NAFLD patients.ResultsHigher age, female gender, higher BMI, triglyceride, waist and hip circumference and waist-to-hip ratio were found in pre-diabetic NAFLD individuals compared with normoglycemic ones (P-value<0.05). Multivariable age-, sex-, BMI- and smoking- adjusted logistic regression showed a predicting role of pre-diabetes and NAFLD concurrence with metabolic syndrome (P-value<0.001, OR:4.31, 95% CI: 2.95- 6.29), but not CVD (P-value=0.353, OR:1.37, 95% CI: 0.71- 2.61).ConclusionIn this study, nearly one-third of NAFLD patients had pre-diabetes. The mean value of age, BMI, TG, waist and Hip circumference was significantly higher in pre-diabetic patients. The concurrence of pre-diabetes and NAFLD was a predicting factor for metabolic syndrome, but not CVD events.https://www.frontiersin.org/articles/10.3389/fendo.2025.1416407/fullnon-alcoholic fatty liver disease (NAFLD)pre-diabetesdiabetescardiometabolic risk factorsBMImetabolic syndrome |
| spellingShingle | Azam Teimouri Zahra Ebrahimpour Awat Feizi Bijan Iraj Elahe Saffari Mojtaba Akbari Mozhgan Karimifar Pre-diabetes and cardiovascular risk factors in NAFLD patients: a retrospective comparative analysis Frontiers in Endocrinology non-alcoholic fatty liver disease (NAFLD) pre-diabetes diabetes cardiometabolic risk factors BMI metabolic syndrome |
| title | Pre-diabetes and cardiovascular risk factors in NAFLD patients: a retrospective comparative analysis |
| title_full | Pre-diabetes and cardiovascular risk factors in NAFLD patients: a retrospective comparative analysis |
| title_fullStr | Pre-diabetes and cardiovascular risk factors in NAFLD patients: a retrospective comparative analysis |
| title_full_unstemmed | Pre-diabetes and cardiovascular risk factors in NAFLD patients: a retrospective comparative analysis |
| title_short | Pre-diabetes and cardiovascular risk factors in NAFLD patients: a retrospective comparative analysis |
| title_sort | pre diabetes and cardiovascular risk factors in nafld patients a retrospective comparative analysis |
| topic | non-alcoholic fatty liver disease (NAFLD) pre-diabetes diabetes cardiometabolic risk factors BMI metabolic syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1416407/full |
| work_keys_str_mv | AT azamteimouri prediabetesandcardiovascularriskfactorsinnafldpatientsaretrospectivecomparativeanalysis AT zahraebrahimpour prediabetesandcardiovascularriskfactorsinnafldpatientsaretrospectivecomparativeanalysis AT awatfeizi prediabetesandcardiovascularriskfactorsinnafldpatientsaretrospectivecomparativeanalysis AT bijaniraj prediabetesandcardiovascularriskfactorsinnafldpatientsaretrospectivecomparativeanalysis AT elahesaffari prediabetesandcardiovascularriskfactorsinnafldpatientsaretrospectivecomparativeanalysis AT mojtabaakbari prediabetesandcardiovascularriskfactorsinnafldpatientsaretrospectivecomparativeanalysis AT mozhgankarimifar prediabetesandcardiovascularriskfactorsinnafldpatientsaretrospectivecomparativeanalysis |