Inhibition of a Myotoxic Phospholipase A2 isolated from Crotalus durissus cumanensis by Pentacyclic Triterpenes

Inhibition of a Myotoxic Phospholipase A2 isolated from Crotalus durissus cumanensis by Pentacyclic Triterpenes

BACKGROUND: Ophidian accidents have been recognized as public health events in Colombia since 2004 and have been systematically reported since 2007, constituting a significant public health problem. One of the components present in the venoms of Viperidae snakes is the phospholipase A2 (PLA2) enzyme...

Full description

Saved in:

Bibliographic Details
Main Authors:	Laura Cardona-Alzate, Lina Maria Preciado-Rojo, Isabela Barahona-Sanchez, Vanesa Cardona-Cartagena, Jaime Andres Pereañez
Format:	Article
Language:	English
Published:	Universidad de Antioquia 2025-03-01
Series:	Vitae
Subjects:	Phospholipase A2 triterpenic compounds molecular docking snake venom Crotalus durissus cumanensis
Online Access:	https://revistas.udea.edu.co/index.php/vitae/article/view/356555
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Comparative Analysis of the Enzymatic, Coagulant, and Neuromuscular Activities of Two Variants of <i>Crotalus durissus ruruima</i> Venom and Antivenom Efficacy
by: Poliana J. Demico, et al.
Published: (2025-01-01)

An updated review deciphering the anticancer potential of pentacyclic triterpene lupeol and its nanoformulations
by: Lujain A. AlMousa, et al.
Published: (2025-05-01)

Venom Peptides of Crotalus atrox Against SARS-Cov-2 Spike Protein and Human ACE2 Receptor by Molecular Docking Analysis
by: Süleyman İlhan
Published: (2023-08-01)

New triterpene isovanniloyl and antibacterial activity of constituents from the roots of Paullinia pinnata Linn (Sapindaceae)
by: A.A. Lasisi, et al.
Published: (2015-03-01)

TRITERPENE GLYCOSIDES OF HERB OF SOLIDAGO CAUCASICA KEM.-NATH.
by: V. V. Fedotova, et al.
Published: (2015-09-01)

Ultrasound-assisted extraction, enrichment, and hypolipidemic potential of triterpenes from Grifola frondosa mycelia
by: Chenmeng Wan, et al.
Published: (2025-06-01)

Serpentifauna de la Llanura Costera del Caribe
by: Dugand Armando
Published: (1975-09-01)

Human phospholipases A2: a functional and evolutionary analysis
by: I. I. Turnaev, et al.
Published: (2023-01-01)

Anticancer activity of triterpene glycosides from the sea star Solaster pacificus
by: Sergey A. Dyshlovoy, et al.
Published: (2025-08-01)

Design and synthesis of 3,4-seco-lupane triterpene-tryptamine derivatives and revealing their anti-bladder cancer mechanisms by combining TCGA and transcriptomic approaches
by: Qinglong Chi, et al.
Published: (2025-06-01)

Deciphering the Phytochemical Potential of Hemp Hairy Roots: A Promising Source of Cannabisins and Triterpenes as Bioactive Compounds
by: Naomi Kaminsky, et al.
Published: (2024-12-01)

Crotalus durissus terrificus Venom Interferes With Morphological, Functional, and Biochemical Changes in Murine Macrophage
by: Anselmo Hernández Cruz, et al.
Published: (2005-01-01)

Inflammatory Mediators Release in Urine from Mice Injected with Crotalus durissus terrificus Venom
by: A. Hernández Cruz, et al.
Published: (2011-01-01)

A triterpene-enriched natural extract from Eucalyptus tereticornis modulates the expression of genes involved in adipogenesis, lipolysis, and extracellular matrix remodeling in a primary human and mouse cell line adipocyte
by: Sergio Acin, et al.
Published: (2025-12-01)

Phospholipases A and Lysophospholipases in protozoan parasites
by: Perrine Hervé, et al.
Published: (2023-10-01)

Ursane Triterpenes and Norisoprenoids from <i>Anchusa italica</i> Retz. and Their Chemotaxonomic Significance
by: Linchuang Shen, et al.
Published: (2025-05-01)

Screening Mutagenic Strains with High Triterpene Content from Sanghuangporus baumii and Studying Their Antioxidant Capacity
by: YaWei Li, et al.
Published: (2025-07-01)

Phenotypic dichotomy in Crotalus durissus ruruima venom and potential consequences for clinical management of snakebite envenomations.
by: Mônica Colombini, et al.
Published: (2025-08-01)

Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis
by: Dharmendra Kumar, et al.
Published: (2015-04-01)

Value of M-type phospholipase A2 receptor in clinical diagnosis and treatment of membranous nephropathy:recent advances and current controversies
by: Wang Hui, et al.
Published: (2021-01-01)

Fungistatic effect of Gracilaria verrucosa on phospholipase enzymes and the cell surface hydrophobicity of Candida albicans
by: Basri A. Gani, et al.
Published: (2025-03-01)

Isomeric Differentiation of Four Triterpene Acids Using Full Collision Energy Ramp-MS2 Analysis
by: Li-juan WU, et al.
Published: (2025-01-01)

Design and synthesis of 3,4-seco-Lupane triterpene derivatives: targeting tumor angiogenesis and inducing apoptosis in triple-negative breast cancer
by: Chunyu Gao, et al.
Published: (2025-07-01)

Identification and Expression Analysis of the Phospholipase D Gene Family in Rice
by: Huasheng CAO, et al.
Published: (2024-12-01)

Viperidae snake venom phospholipase A2 . Biochemical targets for the action of protein in the human blood circulatory system. Part 1 (review of literature)
by: L. V. Galebskaya, et al.
Published: (2022-05-01)

Simultaneous Quantification of Bioactive Triterpene Saponins Calenduloside E and Chikusetsusaponin IVa in Different Plant Parts of Ten Amaranthaceae Species by UPLC-ESI-MS/MS Method
by: Karolina Grabowska, et al.
Published: (2025-02-01)

Triterpene esters from Uncaria rhynchophylla hooks as potent HIV-1 protease inhibitors and their molecular docking study
by: JiSuk Lee
Published: (2024-12-01)

Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice
by: S. S. Khizrieva, et al.
Published: (2020-12-01)

The screened triterpene acids from Loquat fruit by CysLTR1-immobilized column could serve as alternative anti-inflammatory agents
by: Tian Yang, et al.
Published: (2025-07-01)

Cladolosides of Groups S and T: Triterpene Glycosides from the Sea Cucumber <i>Cladolabes schmeltzii</i> with Unique Sulfation; Human Breast Cancer Cytotoxicity and QSAR
by: Alexandra S. Silchenko, et al.
Published: (2025-06-01)

Viperidae snake venom phospholipase A2. Biochemical targets in the human blood circulatory system. Review. Part 2
by: L. V. Vasina, et al.
Published: (2024-04-01)

Sperm storage in males of the Neotropical rattlesnake Crotalus durissus (Squamata: Viperidae): Structure and seasonal variation of the distal ductus deferens
by: Leonardo Carvalho, et al.
Published: (2024-01-01)

Wounding and Phospholipase C Inhibition: Evaluation of the Alkaloid Profiling in Opium Poppy
by: Barbora Hans, et al.
Published: (2025-05-01)

Contribution of individual phospholipase A2 enzymes to the cleavage of oxidized phospholipids in human blood plasma
by: Philipp Jokesch, et al.
Published: (2025-02-01)

Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi
by: Mayara S. Bertolini, et al.
Published: (2025-05-01)

In vitro investigation of the antiparasitic effects of a pentacyclic triterpene from the toothache plant on intestinal worms of poultry
by: Pawi Bawitlung Lalthanpuii, et al.
Published: (2025-03-01)

Overproduction and Characterization of Recombinant Soluble Trypanosoma brucei Phospholipase A2
by: Oluwafemi Abiodun Adepoju, et al.
Published: (2025-03-01)

Ecophysiological Responses of Triterpene Glycosides in Buds of <i>Aralia elata</i> (Miq.) Seem. to Late Spring Frost with Soil-Mediated Effects
by: Ning Wang, et al.
Published: (2025-07-01)

The correlation between anti-phospholipase A2 receptor antibodies and hypercoagulability in patients with idiopathic membranous nephropathy
by: Yunyun Liu, et al.
Published: (2024-12-01)

Molecular interaction assays in silico of crotapotin from Crotalus durissus terrificus against the molecular target trypanothione reductase from Leishmania braziliensis
by: Jamile Mariano Macedo, et al.
Published: (2025-04-01)