Clinical Characteristics and Outcome of Kidney Transplant Recipients Infected with COVID-19: A Retrospective Observational Study
Background: This study investigated the clinical characteristics and outcomes of kidney transplant recipients (KTRs) who contracted COVID-19. Methods: In this retrospective study, we analyzed data from 122 KTRs confirmed to have COVID-19. Results: The mean age in patients with mild COVID-19 disease...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Indian Journal of Transplantation |
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| Online Access: | https://journals.lww.com/10.4103/ijot.ijot_6_24 |
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| author | Manzoor Ahmad Parry Rayees Yousuf Sheikh Raja Kaamil Qadri Muzafar Maqsood Wani Imtiyaz Wani Mohammad Ashraf Bhat |
| author_facet | Manzoor Ahmad Parry Rayees Yousuf Sheikh Raja Kaamil Qadri Muzafar Maqsood Wani Imtiyaz Wani Mohammad Ashraf Bhat |
| author_sort | Manzoor Ahmad Parry |
| collection | DOAJ |
| description | Background:
This study investigated the clinical characteristics and outcomes of kidney transplant recipients (KTRs) who contracted COVID-19.
Methods:
In this retrospective study, we analyzed data from 122 KTRs confirmed to have COVID-19.
Results:
The mean age in patients with mild COVID-19 disease was 37.1 ± 9.1 years, whereas those with moderate and severe disease were 44.7 ± 13.7 and 48.1 ± 11.2 years, respectively (P = 0.02). The median neutrophil-to-lymphocyte ratio was 4.2 (interquartile range [IQR] 3.0–6.8) for mild cases, 6.5 (IQR: 5.0–10.8) for moderate cases, and 19 (IQR: 7.0–24.7) for severe cases (P = 0.008). The median C-reactive protein (CRP) levels (mg/L) were 19.5 (1QR: 5.0–156.3), 53.9 (1QR: 31.5–96.0), and 63.4 (1QR: 23.2–228) for mild, moderate, and severe cases, respectively (P = 0.006). Acute kidney injury occurred in 13.6%, 60%, and 81.57% of patients with mild, moderate, and severe cases, respectively (P = 0.004). Risk factors for a composite outcome of death and dialysis included age >50 years (odds ratio [OR]: 3.25, confidence interval [CI]: 1.25–7.7; P = 0.027), nonvaccinated status (OR 2.87, CI: 1.56–4.18; P = 0.008), graft dysfunction (OR: 2.1, CI: 1.2–5.9; P = 0.034), and CT severity index (CTSI) >13 (OR 3.3, CI: 1.5–5.9; P = 0.040).
Conclusions:
COVID-19 infection in KTRs is linked to a high mortality rate. Advanced age, lymphopenia, elevated CRP levels, and acute graft dysfunction are associated with disease severity. Age >50 years, nonvaccinated status, graft dysfunction, and a CTSI >13 are risk factors for the composite outcome of death and dialysis. |
| format | Article |
| id | doaj-art-7a606816dff5450fb3d5847f78ccc1fc |
| institution | Kabale University |
| issn | 2212-0017 2212-0025 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Transplantation |
| spelling | doaj-art-7a606816dff5450fb3d5847f78ccc1fc2025-01-07T06:12:53ZengWolters Kluwer Medknow PublicationsIndian Journal of Transplantation2212-00172212-00252024-12-0118437938410.4103/ijot.ijot_6_24Clinical Characteristics and Outcome of Kidney Transplant Recipients Infected with COVID-19: A Retrospective Observational StudyManzoor Ahmad ParryRayees Yousuf SheikhRaja Kaamil QadriMuzafar Maqsood WaniImtiyaz WaniMohammad Ashraf BhatBackground: This study investigated the clinical characteristics and outcomes of kidney transplant recipients (KTRs) who contracted COVID-19. Methods: In this retrospective study, we analyzed data from 122 KTRs confirmed to have COVID-19. Results: The mean age in patients with mild COVID-19 disease was 37.1 ± 9.1 years, whereas those with moderate and severe disease were 44.7 ± 13.7 and 48.1 ± 11.2 years, respectively (P = 0.02). The median neutrophil-to-lymphocyte ratio was 4.2 (interquartile range [IQR] 3.0–6.8) for mild cases, 6.5 (IQR: 5.0–10.8) for moderate cases, and 19 (IQR: 7.0–24.7) for severe cases (P = 0.008). The median C-reactive protein (CRP) levels (mg/L) were 19.5 (1QR: 5.0–156.3), 53.9 (1QR: 31.5–96.0), and 63.4 (1QR: 23.2–228) for mild, moderate, and severe cases, respectively (P = 0.006). Acute kidney injury occurred in 13.6%, 60%, and 81.57% of patients with mild, moderate, and severe cases, respectively (P = 0.004). Risk factors for a composite outcome of death and dialysis included age >50 years (odds ratio [OR]: 3.25, confidence interval [CI]: 1.25–7.7; P = 0.027), nonvaccinated status (OR 2.87, CI: 1.56–4.18; P = 0.008), graft dysfunction (OR: 2.1, CI: 1.2–5.9; P = 0.034), and CT severity index (CTSI) >13 (OR 3.3, CI: 1.5–5.9; P = 0.040). Conclusions: COVID-19 infection in KTRs is linked to a high mortality rate. Advanced age, lymphopenia, elevated CRP levels, and acute graft dysfunction are associated with disease severity. Age >50 years, nonvaccinated status, graft dysfunction, and a CTSI >13 are risk factors for the composite outcome of death and dialysis.https://journals.lww.com/10.4103/ijot.ijot_6_24acute kidney injuryinterleukin-6kidney transplant recipientssars-cov-2 |
| spellingShingle | Manzoor Ahmad Parry Rayees Yousuf Sheikh Raja Kaamil Qadri Muzafar Maqsood Wani Imtiyaz Wani Mohammad Ashraf Bhat Clinical Characteristics and Outcome of Kidney Transplant Recipients Infected with COVID-19: A Retrospective Observational Study Indian Journal of Transplantation acute kidney injury interleukin-6 kidney transplant recipients sars-cov-2 |
| title | Clinical Characteristics and Outcome of Kidney Transplant Recipients Infected with COVID-19: A Retrospective Observational Study |
| title_full | Clinical Characteristics and Outcome of Kidney Transplant Recipients Infected with COVID-19: A Retrospective Observational Study |
| title_fullStr | Clinical Characteristics and Outcome of Kidney Transplant Recipients Infected with COVID-19: A Retrospective Observational Study |
| title_full_unstemmed | Clinical Characteristics and Outcome of Kidney Transplant Recipients Infected with COVID-19: A Retrospective Observational Study |
| title_short | Clinical Characteristics and Outcome of Kidney Transplant Recipients Infected with COVID-19: A Retrospective Observational Study |
| title_sort | clinical characteristics and outcome of kidney transplant recipients infected with covid 19 a retrospective observational study |
| topic | acute kidney injury interleukin-6 kidney transplant recipients sars-cov-2 |
| url | https://journals.lww.com/10.4103/ijot.ijot_6_24 |
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