Role of Gut Microbiota and Metabolite Remodeling on the Development and Management of Rheumatoid Arthritis: A Narrative Review
Rheumatoid arthritis (RA) is a chronic autoimmune disease that has a serious impact on both human health and animal production. The gut microbiota is a large and complex symbiotic ecosystem in animals, and the imbalance of gut microbiota is closely related to the pathogenesis of numerous diseases, i...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
|
| Series: | Veterinary Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-7381/12/7/642 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849713231416786944 |
|---|---|
| author | Yichen Yu Fulin Jin Lijun Wang Ji Cheng Shifeng Pan |
| author_facet | Yichen Yu Fulin Jin Lijun Wang Ji Cheng Shifeng Pan |
| author_sort | Yichen Yu |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a chronic autoimmune disease that has a serious impact on both human health and animal production. The gut microbiota is a large and complex symbiotic ecosystem in animals, and the imbalance of gut microbiota is closely related to the pathogenesis of numerous diseases, including RA. The interactions among the gut microbiota, intestinal barrier, and immune system play key roles in maintaining intestinal homeostasis and affecting the development of RA. Regulating intestinal flora and metabolites provides new ideas for the prevention and treatment of RA. Probiotics can regulate the balance of intestinal flora and metabolites, improve the immune environment, and provide novel therapeutic strategies against RA. In order to summarize the role of gut microbiota and metabolite remodeling in the development and management of RA, this review will elaborate on the role of intestinal flora imbalance in the pathogenesis of RA and assess prospective therapeutic approaches that target the gut flora. Understanding the interaction among intestinal flora, metabolites, and RA will help to clarify the pathogenesis of RA and develop innovative and personalized therapeutic interventions against chronic autoimmune diseases. |
| format | Article |
| id | doaj-art-7a5f778f78ba4dd8b0ced32fa7c7cddf |
| institution | DOAJ |
| issn | 2306-7381 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj-art-7a5f778f78ba4dd8b0ced32fa7c7cddf2025-08-20T03:14:01ZengMDPI AGVeterinary Sciences2306-73812025-07-0112764210.3390/vetsci12070642Role of Gut Microbiota and Metabolite Remodeling on the Development and Management of Rheumatoid Arthritis: A Narrative ReviewYichen Yu0Fulin Jin1Lijun Wang2Ji Cheng3Shifeng Pan4College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ChinaRheumatoid arthritis (RA) is a chronic autoimmune disease that has a serious impact on both human health and animal production. The gut microbiota is a large and complex symbiotic ecosystem in animals, and the imbalance of gut microbiota is closely related to the pathogenesis of numerous diseases, including RA. The interactions among the gut microbiota, intestinal barrier, and immune system play key roles in maintaining intestinal homeostasis and affecting the development of RA. Regulating intestinal flora and metabolites provides new ideas for the prevention and treatment of RA. Probiotics can regulate the balance of intestinal flora and metabolites, improve the immune environment, and provide novel therapeutic strategies against RA. In order to summarize the role of gut microbiota and metabolite remodeling in the development and management of RA, this review will elaborate on the role of intestinal flora imbalance in the pathogenesis of RA and assess prospective therapeutic approaches that target the gut flora. Understanding the interaction among intestinal flora, metabolites, and RA will help to clarify the pathogenesis of RA and develop innovative and personalized therapeutic interventions against chronic autoimmune diseases.https://www.mdpi.com/2306-7381/12/7/642rheumatoid arthritisintestinal microbiotaanimal productionintestinal barrierimmune responseprobiotic therapy |
| spellingShingle | Yichen Yu Fulin Jin Lijun Wang Ji Cheng Shifeng Pan Role of Gut Microbiota and Metabolite Remodeling on the Development and Management of Rheumatoid Arthritis: A Narrative Review Veterinary Sciences rheumatoid arthritis intestinal microbiota animal production intestinal barrier immune response probiotic therapy |
| title | Role of Gut Microbiota and Metabolite Remodeling on the Development and Management of Rheumatoid Arthritis: A Narrative Review |
| title_full | Role of Gut Microbiota and Metabolite Remodeling on the Development and Management of Rheumatoid Arthritis: A Narrative Review |
| title_fullStr | Role of Gut Microbiota and Metabolite Remodeling on the Development and Management of Rheumatoid Arthritis: A Narrative Review |
| title_full_unstemmed | Role of Gut Microbiota and Metabolite Remodeling on the Development and Management of Rheumatoid Arthritis: A Narrative Review |
| title_short | Role of Gut Microbiota and Metabolite Remodeling on the Development and Management of Rheumatoid Arthritis: A Narrative Review |
| title_sort | role of gut microbiota and metabolite remodeling on the development and management of rheumatoid arthritis a narrative review |
| topic | rheumatoid arthritis intestinal microbiota animal production intestinal barrier immune response probiotic therapy |
| url | https://www.mdpi.com/2306-7381/12/7/642 |
| work_keys_str_mv | AT yichenyu roleofgutmicrobiotaandmetaboliteremodelingonthedevelopmentandmanagementofrheumatoidarthritisanarrativereview AT fulinjin roleofgutmicrobiotaandmetaboliteremodelingonthedevelopmentandmanagementofrheumatoidarthritisanarrativereview AT lijunwang roleofgutmicrobiotaandmetaboliteremodelingonthedevelopmentandmanagementofrheumatoidarthritisanarrativereview AT jicheng roleofgutmicrobiotaandmetaboliteremodelingonthedevelopmentandmanagementofrheumatoidarthritisanarrativereview AT shifengpan roleofgutmicrobiotaandmetaboliteremodelingonthedevelopmentandmanagementofrheumatoidarthritisanarrativereview |