Exploring the Skin Benefits of Extremophilic Postbiotics from <i>Exiguobacterium artemiae</i>: A New Frontier in Thermal Protection
Rising global temperatures increase skin exposure to heat stress, which can impair skin structure and function. While several cosmetic ingredients have been developed to mitigate heat-induced damage, most primarily aim to enhance hydration or suppress inflammation, lacking mechanistic insights into...
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MDPI AG
2025-07-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/13/7/1569 |
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| author | Haeun Lee Dayeon Roo Dong-Geol Lee Seunghyun Kang Jinwoo Min Heecheol Kang Young Mok Heo Kyung Eun Lee |
| author_facet | Haeun Lee Dayeon Roo Dong-Geol Lee Seunghyun Kang Jinwoo Min Heecheol Kang Young Mok Heo Kyung Eun Lee |
| author_sort | Haeun Lee |
| collection | DOAJ |
| description | Rising global temperatures increase skin exposure to heat stress, which can impair skin structure and function. While several cosmetic ingredients have been developed to mitigate heat-induced damage, most primarily aim to enhance hydration or suppress inflammation, lacking mechanistic insights into their action under heat stress. This study assessed <i>E. artemiae</i>-derived SUPER-T and its exosome form, Thermasome, in heat-stressed human skin fibroblasts. Transcriptomic profiling revealed that heat stress upregulated heat-related thermal receptors and downregulated key extracellular matrix (ECM)-related genes. Notably, treatment with SUPER-T upregulated expression of these genes, suggesting a reparative role as a barrier to alleviate heat stress at the dermal–epidermal junction. For its application in a field of cosmetics, SUPER-T encapsulated in exosomes (Thermasome) enhanced the heat resilience, suggesting its better transdermal and heat protective effects. Thermasome further improved skin heat resilience and enhanced ECM gene expression including collagen genes. Our findings provide a mechanistic basis for the development of functional cosmetical materials that target ECM remodeling under heat-stressed conditions. |
| format | Article |
| id | doaj-art-7a5c17d1898e4e5dbc80cf5156ddce24 |
| institution | DOAJ |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-7a5c17d1898e4e5dbc80cf5156ddce242025-08-20T03:08:06ZengMDPI AGMicroorganisms2076-26072025-07-01137156910.3390/microorganisms13071569Exploring the Skin Benefits of Extremophilic Postbiotics from <i>Exiguobacterium artemiae</i>: A New Frontier in Thermal ProtectionHaeun Lee0Dayeon Roo1Dong-Geol Lee2Seunghyun Kang3Jinwoo Min4Heecheol Kang5Young Mok Heo6Kyung Eun Lee7R&I Center, COSMAX BTI, Pangyo-ro 255, Bundang-gu, Seongnam 13486, Republic of KoreaR&I Center, COSMAX BTI, Pangyo-ro 255, Bundang-gu, Seongnam 13486, Republic of KoreaR&I Center, COSMAX BTI, Pangyo-ro 255, Bundang-gu, Seongnam 13486, Republic of KoreaR&I Center, COSMAX BTI, Pangyo-ro 255, Bundang-gu, Seongnam 13486, Republic of KoreaR&I Center, GFC Life Science, Dongtansunhwan-daero 823, Hwaseong 18471, Republic of KoreaR&I Center, GFC Life Science, Dongtansunhwan-daero 823, Hwaseong 18471, Republic of KoreaR&I Center, COSMAX BTI, Pangyo-ro 255, Bundang-gu, Seongnam 13486, Republic of KoreaR&I Center, COSMAX BTI, Pangyo-ro 255, Bundang-gu, Seongnam 13486, Republic of KoreaRising global temperatures increase skin exposure to heat stress, which can impair skin structure and function. While several cosmetic ingredients have been developed to mitigate heat-induced damage, most primarily aim to enhance hydration or suppress inflammation, lacking mechanistic insights into their action under heat stress. This study assessed <i>E. artemiae</i>-derived SUPER-T and its exosome form, Thermasome, in heat-stressed human skin fibroblasts. Transcriptomic profiling revealed that heat stress upregulated heat-related thermal receptors and downregulated key extracellular matrix (ECM)-related genes. Notably, treatment with SUPER-T upregulated expression of these genes, suggesting a reparative role as a barrier to alleviate heat stress at the dermal–epidermal junction. For its application in a field of cosmetics, SUPER-T encapsulated in exosomes (Thermasome) enhanced the heat resilience, suggesting its better transdermal and heat protective effects. Thermasome further improved skin heat resilience and enhanced ECM gene expression including collagen genes. Our findings provide a mechanistic basis for the development of functional cosmetical materials that target ECM remodeling under heat-stressed conditions.https://www.mdpi.com/2076-2607/13/7/1569<i>Exiguobacterium aurantiacum</i>extremophileheat-stressnidogenbasement membranethermasome |
| spellingShingle | Haeun Lee Dayeon Roo Dong-Geol Lee Seunghyun Kang Jinwoo Min Heecheol Kang Young Mok Heo Kyung Eun Lee Exploring the Skin Benefits of Extremophilic Postbiotics from <i>Exiguobacterium artemiae</i>: A New Frontier in Thermal Protection Microorganisms <i>Exiguobacterium aurantiacum</i> extremophile heat-stress nidogen basement membrane thermasome |
| title | Exploring the Skin Benefits of Extremophilic Postbiotics from <i>Exiguobacterium artemiae</i>: A New Frontier in Thermal Protection |
| title_full | Exploring the Skin Benefits of Extremophilic Postbiotics from <i>Exiguobacterium artemiae</i>: A New Frontier in Thermal Protection |
| title_fullStr | Exploring the Skin Benefits of Extremophilic Postbiotics from <i>Exiguobacterium artemiae</i>: A New Frontier in Thermal Protection |
| title_full_unstemmed | Exploring the Skin Benefits of Extremophilic Postbiotics from <i>Exiguobacterium artemiae</i>: A New Frontier in Thermal Protection |
| title_short | Exploring the Skin Benefits of Extremophilic Postbiotics from <i>Exiguobacterium artemiae</i>: A New Frontier in Thermal Protection |
| title_sort | exploring the skin benefits of extremophilic postbiotics from i exiguobacterium artemiae i a new frontier in thermal protection |
| topic | <i>Exiguobacterium aurantiacum</i> extremophile heat-stress nidogen basement membrane thermasome |
| url | https://www.mdpi.com/2076-2607/13/7/1569 |
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