HOXB and HOXD genes contribute to the carcinogenic processes in glioblastoma: evidence form a bioinformatics analysis
Purpose: Glioblastoma is an aggressive cancer that affects the brain. The Homeobox B and D (HOXB/D) family has been linked to tumor progression, but their exact mechanism remains unclear. Material and methods: This study aimed to identify critical HOXB/D family members associated with glioblastoma a...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Cancer Treatment and Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294225000607 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Purpose: Glioblastoma is an aggressive cancer that affects the brain. The Homeobox B and D (HOXB/D) family has been linked to tumor progression, but their exact mechanism remains unclear. Material and methods: This study aimed to identify critical HOXB/D family members associated with glioblastoma and analyze their expression in glioblastoma using the GEPIA2 database. The study also assessed genetic alterations, their related transcription factors, miRNAs, gene-gene interactions, and correlations between their expression and immune infiltration using databases like cBioPortal, miRNet, GeneMANIA, and GSCA. Results: We showed that HOXB2/3/7 and HOXD3/8/9/10/11/13 expression was higher in glioblastoma samples compared to normal samples. Increased expression of HOXB2/5/8/9/13 was associated with negative effects on overall survival (OS), disease-specific survival (DSS), and progression-free survival (PFS), while overexpression of HOXB2/5/9 was linked to inferior PFS. Heightened levels of HOXD4/9, HOXD9/11, and HOXD9/10/11 expression in glioblastoma patients were correlated with unfavorable outcomes in terms of OS, DSS, and PFS. HOXB/D genes were related to 20 different genes, mainly enriched in the Activation of HOX Genes During Differentiation R-HSA-5619507 pathway. Immune cells were linked to specific genes in glioblastoma, with HOXB2 and HOXD3 expression potentially causing resistance to Methotrexate and Z-LLNle-CHO, HOXB7 indicating sensitivity to Lapatinib but resistance to 18 other small molecules, HOXD8 leading to resistance against 5 small molecules, and upregulated HOXD9, HOXD10, and HOXD13 suggesting sensitivity to 2, 4, and 9 small molecules, respectively. Conclusion: Taken together, we showed contribution of HOXB and HOXD genes in the carcinogenic processes and proposed them as possible targets for treatment options. |
|---|---|
| ISSN: | 2468-2942 |