Challenges and practical considerations in the management of blastic plasmacytoid dendritic cell neoplasm: A single-center experience
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is a rare and often life-threatening complex hematologic malignancy that can commonly infiltrate the skin, lymph nodes, central nervous system, and bone marrow. In the setting of the infrequency of confirmed diagnoses of BPDCN, and given limited p...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Leukemia Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048924000761 |
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| author | Haripriya Andanamala Naveen Pemmaraju Taha Al-Juhaishi |
| author_facet | Haripriya Andanamala Naveen Pemmaraju Taha Al-Juhaishi |
| author_sort | Haripriya Andanamala |
| collection | DOAJ |
| description | Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is a rare and often life-threatening complex hematologic malignancy that can commonly infiltrate the skin, lymph nodes, central nervous system, and bone marrow. In the setting of the infrequency of confirmed diagnoses of BPDCN, and given limited prospective studies, it has been associated with lackluster outcomes with a median overall survival between 9 and 23 months. We herein discuss our experience treating five consecutive patients with BPDCN at our center since the approval of TAG. We also present some of the challenges that face oncology providers treating this disease due to exceptional rarity and aggressive nature of this disease in addition to overall limited experience and effective therapies |
| format | Article |
| id | doaj-art-7a4ba092ff6b4a69831d4d9b16fcb0de |
| institution | Kabale University |
| issn | 2213-0489 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj-art-7a4ba092ff6b4a69831d4d9b16fcb0de2024-12-06T05:13:28ZengElsevierLeukemia Research Reports2213-04892024-01-0122100486Challenges and practical considerations in the management of blastic plasmacytoid dendritic cell neoplasm: A single-center experienceHaripriya Andanamala0Naveen Pemmaraju1Taha Al-Juhaishi2OU Stephenson Cancer Center, Oklahoma City, OK, United StatesUniversity of Texas MD Anderson Cancer Center, Houston, TX, United StatesOU Stephenson Cancer Center, Oklahoma City, OK, United States; Corresponding author at: Stem Cell Transplantation and Cellular Therapy Program, Department of Medicine – Section of Hematology and Medical Oncology, University of Oklahoma Health Sciences Center - Stephenson Cancer Center, 800 NE 10th Street, office # 5023; Oklahoma City, Oklahoma, 73104, United States.Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is a rare and often life-threatening complex hematologic malignancy that can commonly infiltrate the skin, lymph nodes, central nervous system, and bone marrow. In the setting of the infrequency of confirmed diagnoses of BPDCN, and given limited prospective studies, it has been associated with lackluster outcomes with a median overall survival between 9 and 23 months. We herein discuss our experience treating five consecutive patients with BPDCN at our center since the approval of TAG. We also present some of the challenges that face oncology providers treating this disease due to exceptional rarity and aggressive nature of this disease in addition to overall limited experience and effective therapieshttp://www.sciencedirect.com/science/article/pii/S2213048924000761BPDCNStem cell transplantationTargeted therapyRare cancersCase series |
| spellingShingle | Haripriya Andanamala Naveen Pemmaraju Taha Al-Juhaishi Challenges and practical considerations in the management of blastic plasmacytoid dendritic cell neoplasm: A single-center experience Leukemia Research Reports BPDCN Stem cell transplantation Targeted therapy Rare cancers Case series |
| title | Challenges and practical considerations in the management of blastic plasmacytoid dendritic cell neoplasm: A single-center experience |
| title_full | Challenges and practical considerations in the management of blastic plasmacytoid dendritic cell neoplasm: A single-center experience |
| title_fullStr | Challenges and practical considerations in the management of blastic plasmacytoid dendritic cell neoplasm: A single-center experience |
| title_full_unstemmed | Challenges and practical considerations in the management of blastic plasmacytoid dendritic cell neoplasm: A single-center experience |
| title_short | Challenges and practical considerations in the management of blastic plasmacytoid dendritic cell neoplasm: A single-center experience |
| title_sort | challenges and practical considerations in the management of blastic plasmacytoid dendritic cell neoplasm a single center experience |
| topic | BPDCN Stem cell transplantation Targeted therapy Rare cancers Case series |
| url | http://www.sciencedirect.com/science/article/pii/S2213048924000761 |
| work_keys_str_mv | AT haripriyaandanamala challengesandpracticalconsiderationsinthemanagementofblasticplasmacytoiddendriticcellneoplasmasinglecenterexperience AT naveenpemmaraju challengesandpracticalconsiderationsinthemanagementofblasticplasmacytoiddendriticcellneoplasmasinglecenterexperience AT tahaaljuhaishi challengesandpracticalconsiderationsinthemanagementofblasticplasmacytoiddendriticcellneoplasmasinglecenterexperience |