Evaluating the Efficacy of Adjuvant Radiotherapy in the Management of Advanced Oral Cancer Cases
Background: Because of its high rates of morbidity and death, especially in its late stages, oral cancer poses a serious threat to world health. Even with improvements in surgical and chemotherapeutic techniques, advanced oral cancer is still difficult to treat and frequently has unfavorable results...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-08-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_299_24 |
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| author | Radhika Thakkar M. Rama Nalini Rohit K. Jha Mudita Chaturvedi Raja S. Prathigudupu S. Hemavathy B S Dayanithi |
| author_facet | Radhika Thakkar M. Rama Nalini Rohit K. Jha Mudita Chaturvedi Raja S. Prathigudupu S. Hemavathy B S Dayanithi |
| author_sort | Radhika Thakkar |
| collection | DOAJ |
| description | Background:
Because of its high rates of morbidity and death, especially in its late stages, oral cancer poses a serious threat to world health. Even with improvements in surgical and chemotherapeutic techniques, advanced oral cancer is still difficult to treat and frequently has unfavorable results.
Methods:
Information on demographics, tumor features, treatment options, and results were gathered from medical records. Patients were categorized according to whether they underwent surgery alone or adjuvant radiation treatment after initial surgical resection. For the survival analysis, Kaplan–Meier curves and Cox proportional hazards models were employed.
Results:
There were 150 patients in all, 75 in each group, who took part in the trial. Comparing adjuvant radiation to surgery alone resulted in considerably better overall survival (P < 0.001) and disease-free survival (P < 0.001). However, problems connected to the adjuvant radiation group affected a portion of the patient population.
Conclusion:
In conclusion, patients with advanced oral cancer can improve their overall and disease-free survival with adjuvant radiation, a successful therapeutic option. To maximize results, nevertheless, cautious patient selection and effective management of treatment-related problems are crucial. To improve treatment algorithms and investigate cutting-edge therapeutic techniques for this difficult condition, further research is necessary. |
| format | Article |
| id | doaj-art-7a49aca34f8f4935b04bf83ab5543dfc |
| institution | OA Journals |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-7a49aca34f8f4935b04bf83ab5543dfc2025-08-20T01:48:10ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-08-0116Suppl 3S2727S272910.4103/jpbs.jpbs_299_24Evaluating the Efficacy of Adjuvant Radiotherapy in the Management of Advanced Oral Cancer CasesRadhika ThakkarM. Rama NaliniRohit K. JhaMudita ChaturvediRaja S. PrathigudupuS. HemavathyB S DayanithiBackground: Because of its high rates of morbidity and death, especially in its late stages, oral cancer poses a serious threat to world health. Even with improvements in surgical and chemotherapeutic techniques, advanced oral cancer is still difficult to treat and frequently has unfavorable results. Methods: Information on demographics, tumor features, treatment options, and results were gathered from medical records. Patients were categorized according to whether they underwent surgery alone or adjuvant radiation treatment after initial surgical resection. For the survival analysis, Kaplan–Meier curves and Cox proportional hazards models were employed. Results: There were 150 patients in all, 75 in each group, who took part in the trial. Comparing adjuvant radiation to surgery alone resulted in considerably better overall survival (P < 0.001) and disease-free survival (P < 0.001). However, problems connected to the adjuvant radiation group affected a portion of the patient population. Conclusion: In conclusion, patients with advanced oral cancer can improve their overall and disease-free survival with adjuvant radiation, a successful therapeutic option. To maximize results, nevertheless, cautious patient selection and effective management of treatment-related problems are crucial. To improve treatment algorithms and investigate cutting-edge therapeutic techniques for this difficult condition, further research is necessary.https://journals.lww.com/10.4103/jpbs.jpbs_299_24advanced stageadjuvant radiationoral cancersurvivaltreatment results |
| spellingShingle | Radhika Thakkar M. Rama Nalini Rohit K. Jha Mudita Chaturvedi Raja S. Prathigudupu S. Hemavathy B S Dayanithi Evaluating the Efficacy of Adjuvant Radiotherapy in the Management of Advanced Oral Cancer Cases Journal of Pharmacy and Bioallied Sciences advanced stage adjuvant radiation oral cancer survival treatment results |
| title | Evaluating the Efficacy of Adjuvant Radiotherapy in the Management of Advanced Oral Cancer Cases |
| title_full | Evaluating the Efficacy of Adjuvant Radiotherapy in the Management of Advanced Oral Cancer Cases |
| title_fullStr | Evaluating the Efficacy of Adjuvant Radiotherapy in the Management of Advanced Oral Cancer Cases |
| title_full_unstemmed | Evaluating the Efficacy of Adjuvant Radiotherapy in the Management of Advanced Oral Cancer Cases |
| title_short | Evaluating the Efficacy of Adjuvant Radiotherapy in the Management of Advanced Oral Cancer Cases |
| title_sort | evaluating the efficacy of adjuvant radiotherapy in the management of advanced oral cancer cases |
| topic | advanced stage adjuvant radiation oral cancer survival treatment results |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_299_24 |
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