OncoBiome: The Emerging Frontier in Cancer-Microbiome Interactions
OncoBiome represents the complex interplay between the human microbiome and cancer biology—a rapidly evolving field investigating how microbial communities influence cancer development, progression, treatment efficacy, and patient outcomes. This bidirectional relationship encompasses multiple dimens...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2025-07-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://ajmsjournal.info/index.php/AJMS/article/view/4629 |
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| author | Ruby Dhar Arun Kumar Subhradip Karmakar |
| author_facet | Ruby Dhar Arun Kumar Subhradip Karmakar |
| author_sort | Ruby Dhar |
| collection | DOAJ |
| description | OncoBiome represents the complex interplay between the human microbiome and cancer biology—a rapidly evolving field investigating how microbial communities influence cancer development, progression, treatment efficacy, and patient outcomes. This bidirectional relationship encompasses multiple dimensions of host-microbe interactions across various body sites and cancer types. Key mechanistic pathways by which the microbiome can influence carcinogenesis involve direct genotoxicity, chronic inflammation leading to persistent microbial dysbiosis, which can create pro-inflammatory environments conducive to cancer development (e.g., H. pylori in gastric cancer, Fusobacterium nucleatum in colorectal cancer). Metabolic modulation involving microbial metabolites like short-chain fatty acids, secondary bile acids, and trimethylamine N-oxide can influence cellular proliferation, apoptosis, and immune function. Further, microbiome composition shapes local and systemic immune responses, potentially affecting immune surveillance of cancer cells. Future research directions include investigating the microbiome's role in Cancer prevention strategies, enhancing immunotherapy response, reducing treatment-related toxicities, developing novel microbiome-based therapeutics, and mitigating cancer recurrence.
The OncoBiome represents a promising frontier in precision oncology, potentially offering new insights for cancer prevention, diagnosis, and treatment through the lens of the human microbiome.
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| format | Article |
| id | doaj-art-7a3e9c75f29a4579b8e8482e52f3fcf8 |
| institution | OA Journals |
| issn | 2467-9100 2091-0576 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj-art-7a3e9c75f29a4579b8e8482e52f3fcf82025-08-20T02:37:51ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762025-07-0116712https://doi.org/10.71152/ajms.v16i7.4629OncoBiome: The Emerging Frontier in Cancer-Microbiome InteractionsRuby Dhar 0https://orcid.org/0000-0003-3600-6554Arun Kumar 1https://orcid.org/0000-0002-8800-0296Subhradip Karmakar 2https://orcid.org/0000-0002-4757-8729Scientist, Department of Biochemistry, All India Institute of Medical Sciences, New Delhi Professor, Department of Biochemistry, Jagannath Gupta Institute of Medical Sciences, Kolkata, West Bengal, India Additional Professor, Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India OncoBiome represents the complex interplay between the human microbiome and cancer biology—a rapidly evolving field investigating how microbial communities influence cancer development, progression, treatment efficacy, and patient outcomes. This bidirectional relationship encompasses multiple dimensions of host-microbe interactions across various body sites and cancer types. Key mechanistic pathways by which the microbiome can influence carcinogenesis involve direct genotoxicity, chronic inflammation leading to persistent microbial dysbiosis, which can create pro-inflammatory environments conducive to cancer development (e.g., H. pylori in gastric cancer, Fusobacterium nucleatum in colorectal cancer). Metabolic modulation involving microbial metabolites like short-chain fatty acids, secondary bile acids, and trimethylamine N-oxide can influence cellular proliferation, apoptosis, and immune function. Further, microbiome composition shapes local and systemic immune responses, potentially affecting immune surveillance of cancer cells. Future research directions include investigating the microbiome's role in Cancer prevention strategies, enhancing immunotherapy response, reducing treatment-related toxicities, developing novel microbiome-based therapeutics, and mitigating cancer recurrence. The OncoBiome represents a promising frontier in precision oncology, potentially offering new insights for cancer prevention, diagnosis, and treatment through the lens of the human microbiome. https://ajmsjournal.info/index.php/AJMS/article/view/4629oncobiome; inflammation; genotoxic effects; cancer; immune surveillance; drug response |
| spellingShingle | Ruby Dhar Arun Kumar Subhradip Karmakar OncoBiome: The Emerging Frontier in Cancer-Microbiome Interactions Asian Journal of Medical Sciences oncobiome; inflammation; genotoxic effects; cancer; immune surveillance; drug response |
| title | OncoBiome: The Emerging Frontier in Cancer-Microbiome Interactions |
| title_full | OncoBiome: The Emerging Frontier in Cancer-Microbiome Interactions |
| title_fullStr | OncoBiome: The Emerging Frontier in Cancer-Microbiome Interactions |
| title_full_unstemmed | OncoBiome: The Emerging Frontier in Cancer-Microbiome Interactions |
| title_short | OncoBiome: The Emerging Frontier in Cancer-Microbiome Interactions |
| title_sort | oncobiome the emerging frontier in cancer microbiome interactions |
| topic | oncobiome; inflammation; genotoxic effects; cancer; immune surveillance; drug response |
| url | https://ajmsjournal.info/index.php/AJMS/article/view/4629 |
| work_keys_str_mv | AT rubydhar oncobiometheemergingfrontierincancermicrobiomeinteractions AT arunkumar oncobiometheemergingfrontierincancermicrobiomeinteractions AT subhradipkarmakar oncobiometheemergingfrontierincancermicrobiomeinteractions |