Familial Reversible Cerebral Vasoconstriction Syndrome: Insights From Two Families

Reversible cerebral vasoconstriction syndrome (RCVS) is a rare condition whose exact underlying mechanisms remain undetermined. Herein, we report two exceptional family cases suggesting that a potential genetic factor might be involved in this condition. A mother and her daughter presented with recu...

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Bibliographic Details
Main Authors: Pacôme Constant dit Beaufils, Benoît Guillon, Hugues Chabriat, Solène de Gaalon
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Case Reports in Neurological Medicine
Online Access:http://dx.doi.org/10.1155/crnm/3126513
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Summary:Reversible cerebral vasoconstriction syndrome (RCVS) is a rare condition whose exact underlying mechanisms remain undetermined. Herein, we report two exceptional family cases suggesting that a potential genetic factor might be involved in this condition. A mother and her daughter presented with recurrent thunderclap headaches and reversible vasoconstriction of the right middle cerebral artery in the first family. Clinical features suggestive of RCVS associated with a discrete subdural hemorrhage was observed in a mother and her daughter in a second family. These familial observations of RCVS suggest the existence of a genetic factor promoting the emergence of this condition.
ISSN:2090-6676