Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats
Diabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/485759 |
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| author | Omar Ortiz-Avila Mauricio Esquivel-Martínez Berenice Eridani Olmos-Orizaba Alfredo Saavedra-Molina Alain R. Rodriguez-Orozco Christian Cortés-Rojo |
| author_facet | Omar Ortiz-Avila Mauricio Esquivel-Martínez Berenice Eridani Olmos-Orizaba Alfredo Saavedra-Molina Alain R. Rodriguez-Orozco Christian Cortés-Rojo |
| author_sort | Omar Ortiz-Avila |
| collection | DOAJ |
| description | Diabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy remains to be clarified, oxidative stress and mitochondrial dysfunction play a crucial role in the pathogenesis of chronic diabetic complications. Taking this into consideration, the aim of this work was to evaluate the effects of 90-day avocado oil intake in brain mitochondrial function and oxidative status in streptozotocin-induced diabetic rats (STZ rats). Avocado oil improves brain mitochondrial function in diabetic rats preventing impairment of mitochondrial respiration and mitochondrial membrane potential ΔΨm, besides increasing complex III activity. Avocado oil also decreased ROS levels and lipid peroxidation and improved the GSH/GSSG ratio as well. These results demonstrate that avocado oil supplementation prevents brain mitochondrial dysfunction induced by diabetes in association with decreased oxidative stress. |
| format | Article |
| id | doaj-art-7a38fc976b5442ae9eb5eeaa2679df32 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-7a38fc976b5442ae9eb5eeaa2679df322025-08-20T03:35:48ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/485759485759Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic RatsOmar Ortiz-Avila0Mauricio Esquivel-Martínez1Berenice Eridani Olmos-Orizaba2Alfredo Saavedra-Molina3Alain R. Rodriguez-Orozco4Christian Cortés-Rojo5Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, 58030 Morelia, MICH, MexicoFacultad de Químico Farmacobiología, Universidad Michoacana de San Nicolás de Hidalgo, 58240 Morelia, MICH, MexicoFacultad de Químico Farmacobiología, Universidad Michoacana de San Nicolás de Hidalgo, 58240 Morelia, MICH, MexicoInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, 58030 Morelia, MICH, MexicoFacultad de Ciencias Médicas y Biológicas “Dr. Ignacio Chávez”, Universidad Michoacana de San Nicolás de Hidalgo, 58020 Morelia, MICH, MexicoInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, 58030 Morelia, MICH, MexicoDiabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy remains to be clarified, oxidative stress and mitochondrial dysfunction play a crucial role in the pathogenesis of chronic diabetic complications. Taking this into consideration, the aim of this work was to evaluate the effects of 90-day avocado oil intake in brain mitochondrial function and oxidative status in streptozotocin-induced diabetic rats (STZ rats). Avocado oil improves brain mitochondrial function in diabetic rats preventing impairment of mitochondrial respiration and mitochondrial membrane potential ΔΨm, besides increasing complex III activity. Avocado oil also decreased ROS levels and lipid peroxidation and improved the GSH/GSSG ratio as well. These results demonstrate that avocado oil supplementation prevents brain mitochondrial dysfunction induced by diabetes in association with decreased oxidative stress.http://dx.doi.org/10.1155/2015/485759 |
| spellingShingle | Omar Ortiz-Avila Mauricio Esquivel-Martínez Berenice Eridani Olmos-Orizaba Alfredo Saavedra-Molina Alain R. Rodriguez-Orozco Christian Cortés-Rojo Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats Journal of Diabetes Research |
| title | Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats |
| title_full | Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats |
| title_fullStr | Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats |
| title_full_unstemmed | Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats |
| title_short | Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats |
| title_sort | avocado oil improves mitochondrial function and decreases oxidative stress in brain of diabetic rats |
| url | http://dx.doi.org/10.1155/2015/485759 |
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