Synthesis and characterization of hydroxyapatite-based nanocomposite coating with alginate biopolymer and MgO nanoparticles for enhanced antibacterial Properties
The objective of this study is to identify the ideal conditions for fabricating hydroxyapatite/alginate/MgO nanocomposite with potent antibacterial. The Taguchi approach was used to investigate the production of nanocomposites with the outstanding antibacterial properties. Three factors were studied...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Open Ceramics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666539525000665 |
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| author | Mohammad Moslem Imani Parya Fatahi Amin Golshah Mohammad Salmani Mobarakeh Mohsen Safaei |
| author_facet | Mohammad Moslem Imani Parya Fatahi Amin Golshah Mohammad Salmani Mobarakeh Mohsen Safaei |
| author_sort | Mohammad Moslem Imani |
| collection | DOAJ |
| description | The objective of this study is to identify the ideal conditions for fabricating hydroxyapatite/alginate/MgO nanocomposite with potent antibacterial. The Taguchi approach was used to investigate the production of nanocomposites with the outstanding antibacterial properties. Three factors were studied at three levels, resulting in nine unique experiments. Characteristics such as surface appearance, chemical composition, elemental dispersion, thermal analysis and crystal structure were all evaluated. The findings showed that MgO nanoparticles and alginate biopolymer were evenly distributed throughout the hydroxyapatite matrix. The nanocomposite produced under experimental conditions 3 (0.03 M hydroxyapatite, 0.04 M alginate, and 0.08 M MgO) showed the strongest impact in inhibiting the growth of Streptococcus mutans at 1.84 Log10 CFU/ml. This study illustrated that the fabricated nanocomposite had a stable performance under ideal conditions and the use of appropriate levels of components enhance the antibacterial activity of the fabricated nanocomposite. |
| format | Article |
| id | doaj-art-7a38a536c6ac4d1399fbc2b6d844d9c8 |
| institution | OA Journals |
| issn | 2666-5395 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Open Ceramics |
| spelling | doaj-art-7a38a536c6ac4d1399fbc2b6d844d9c82025-08-20T02:06:19ZengElsevierOpen Ceramics2666-53952025-06-012210079910.1016/j.oceram.2025.100799Synthesis and characterization of hydroxyapatite-based nanocomposite coating with alginate biopolymer and MgO nanoparticles for enhanced antibacterial PropertiesMohammad Moslem Imani0Parya Fatahi1Amin Golshah2Mohammad Salmani Mobarakeh3Mohsen Safaei4Department of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, IranStudents Research Committee, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, IranAdvanced Dental Science and Technology Research Center, Kermanshah University of Medical Sciences, Kermanshah, IranAdvanced Dental Science and Technology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Division of Dental Biomaterials, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran; Corresponding author.The objective of this study is to identify the ideal conditions for fabricating hydroxyapatite/alginate/MgO nanocomposite with potent antibacterial. The Taguchi approach was used to investigate the production of nanocomposites with the outstanding antibacterial properties. Three factors were studied at three levels, resulting in nine unique experiments. Characteristics such as surface appearance, chemical composition, elemental dispersion, thermal analysis and crystal structure were all evaluated. The findings showed that MgO nanoparticles and alginate biopolymer were evenly distributed throughout the hydroxyapatite matrix. The nanocomposite produced under experimental conditions 3 (0.03 M hydroxyapatite, 0.04 M alginate, and 0.08 M MgO) showed the strongest impact in inhibiting the growth of Streptococcus mutans at 1.84 Log10 CFU/ml. This study illustrated that the fabricated nanocomposite had a stable performance under ideal conditions and the use of appropriate levels of components enhance the antibacterial activity of the fabricated nanocomposite.http://www.sciencedirect.com/science/article/pii/S2666539525000665NanocompositeAntibacterial agentTaguchi methodOral infections |
| spellingShingle | Mohammad Moslem Imani Parya Fatahi Amin Golshah Mohammad Salmani Mobarakeh Mohsen Safaei Synthesis and characterization of hydroxyapatite-based nanocomposite coating with alginate biopolymer and MgO nanoparticles for enhanced antibacterial Properties Open Ceramics Nanocomposite Antibacterial agent Taguchi method Oral infections |
| title | Synthesis and characterization of hydroxyapatite-based nanocomposite coating with alginate biopolymer and MgO nanoparticles for enhanced antibacterial Properties |
| title_full | Synthesis and characterization of hydroxyapatite-based nanocomposite coating with alginate biopolymer and MgO nanoparticles for enhanced antibacterial Properties |
| title_fullStr | Synthesis and characterization of hydroxyapatite-based nanocomposite coating with alginate biopolymer and MgO nanoparticles for enhanced antibacterial Properties |
| title_full_unstemmed | Synthesis and characterization of hydroxyapatite-based nanocomposite coating with alginate biopolymer and MgO nanoparticles for enhanced antibacterial Properties |
| title_short | Synthesis and characterization of hydroxyapatite-based nanocomposite coating with alginate biopolymer and MgO nanoparticles for enhanced antibacterial Properties |
| title_sort | synthesis and characterization of hydroxyapatite based nanocomposite coating with alginate biopolymer and mgo nanoparticles for enhanced antibacterial properties |
| topic | Nanocomposite Antibacterial agent Taguchi method Oral infections |
| url | http://www.sciencedirect.com/science/article/pii/S2666539525000665 |
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