Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis.

Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis.

Retroviral insertional mutagenesis (RIM) is a powerful tool for cancer genomics that was combined in this study with deep sequencing (RIM/DS) to facilitate a comprehensive analysis of lymphoma progression. Transgenic mice expressing two potent collaborating oncogenes in the germ line (CD2-MYC, -Runx...

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Main Authors: Camille A Huser, Kathryn L Gilroy, Jeroen de Ridder, Anna Kilbey, Gillian Borland, Nancy Mackay, Alma Jenkins, Margaret Bell, Pawel Herzyk, Louise van der Weyden, David J Adams, Alistair G Rust, Ewan Cameron, James C Neil
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-02-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1004167
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