Evaluation of Cinnamomum osmophloeum Kanehira Extracts on Tyrosinase Suppressor, Wound Repair Promoter, and Antioxidant
Cinnamomum osmophloeum Kanehira belongs to the Lauraceae family of Taiwan’s endemic plants. In this study, C. osmophloeum Kanehira extract has shown inhibition of tyrosinase activity on B16-F10 cellular system first. Whether extracts inhibited mushroom tyrosinase activity was tested, and a considera...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/303415 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850218735492661248 |
|---|---|
| author | Man-Gang Lee Su-Yu Kuo Shih-Yu Yen Hsia-Fen Hsu Chung-Hang Leung Dik-Lung Ma Zhi-Hong Wen Hui-Min David Wang |
| author_facet | Man-Gang Lee Su-Yu Kuo Shih-Yu Yen Hsia-Fen Hsu Chung-Hang Leung Dik-Lung Ma Zhi-Hong Wen Hui-Min David Wang |
| author_sort | Man-Gang Lee |
| collection | DOAJ |
| description | Cinnamomum osmophloeum Kanehira belongs to the Lauraceae family of Taiwan’s endemic plants. In this study, C. osmophloeum Kanehira extract has shown inhibition of tyrosinase activity on B16-F10 cellular system first. Whether extracts inhibited mushroom tyrosinase activity was tested, and a considerable inhibition of mushroom tyrosinase activity by in vitro assays was presented. Animal experiments of C. osmophloeum Kanehira were carried out by observing animal wound repair, and the extracts had greater wound healing power than the vehicle control group (petroleum jelly with 8% DMSO, w/v). In addition, the antioxidant capacity of C. osmophloeum Kanehira extracts in vitro was evaluated. We measured C. osmophloeum Kanehira extract’s free radical scavenging capability, metal chelating, and reduction power, such as biochemical activity analysis. The results showed that a high concentration of C. osmophloeum Kanehira extract had a significant scavenging capability of free radical, a minor effect of chelating ability, and moderate reducing power. Further exploration of the possible physiological mechanisms and the ingredient components of skincare product for skin-whitening, wound repair, or antioxidative agents are to be done. |
| format | Article |
| id | doaj-art-7a31dcd19fbf4743a845ea5cf6b1e654 |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7a31dcd19fbf4743a845ea5cf6b1e6542025-08-20T02:07:37ZengWileyThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/303415303415Evaluation of Cinnamomum osmophloeum Kanehira Extracts on Tyrosinase Suppressor, Wound Repair Promoter, and AntioxidantMan-Gang Lee0Su-Yu Kuo1Shih-Yu Yen2Hsia-Fen Hsu3Chung-Hang Leung4Dik-Lung Ma5Zhi-Hong Wen6Hui-Min David Wang7Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Fragrance and Cosmetic Science, Graduate Institute of Natural Products, Center for Stem Cell Research, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, TaiwanDepartment of Bioscience Technology, Chang Jung Christian University, Tainan 711, TaiwanMetal Industries Research & Development Centre, Kaohsiung 812, TaiwanState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, MacauDepartment of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong KongDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Fragrance and Cosmetic Science, Graduate Institute of Natural Products, Center for Stem Cell Research, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, TaiwanCinnamomum osmophloeum Kanehira belongs to the Lauraceae family of Taiwan’s endemic plants. In this study, C. osmophloeum Kanehira extract has shown inhibition of tyrosinase activity on B16-F10 cellular system first. Whether extracts inhibited mushroom tyrosinase activity was tested, and a considerable inhibition of mushroom tyrosinase activity by in vitro assays was presented. Animal experiments of C. osmophloeum Kanehira were carried out by observing animal wound repair, and the extracts had greater wound healing power than the vehicle control group (petroleum jelly with 8% DMSO, w/v). In addition, the antioxidant capacity of C. osmophloeum Kanehira extracts in vitro was evaluated. We measured C. osmophloeum Kanehira extract’s free radical scavenging capability, metal chelating, and reduction power, such as biochemical activity analysis. The results showed that a high concentration of C. osmophloeum Kanehira extract had a significant scavenging capability of free radical, a minor effect of chelating ability, and moderate reducing power. Further exploration of the possible physiological mechanisms and the ingredient components of skincare product for skin-whitening, wound repair, or antioxidative agents are to be done.http://dx.doi.org/10.1155/2015/303415 |
| spellingShingle | Man-Gang Lee Su-Yu Kuo Shih-Yu Yen Hsia-Fen Hsu Chung-Hang Leung Dik-Lung Ma Zhi-Hong Wen Hui-Min David Wang Evaluation of Cinnamomum osmophloeum Kanehira Extracts on Tyrosinase Suppressor, Wound Repair Promoter, and Antioxidant The Scientific World Journal |
| title | Evaluation of Cinnamomum osmophloeum Kanehira Extracts on Tyrosinase Suppressor, Wound Repair Promoter, and Antioxidant |
| title_full | Evaluation of Cinnamomum osmophloeum Kanehira Extracts on Tyrosinase Suppressor, Wound Repair Promoter, and Antioxidant |
| title_fullStr | Evaluation of Cinnamomum osmophloeum Kanehira Extracts on Tyrosinase Suppressor, Wound Repair Promoter, and Antioxidant |
| title_full_unstemmed | Evaluation of Cinnamomum osmophloeum Kanehira Extracts on Tyrosinase Suppressor, Wound Repair Promoter, and Antioxidant |
| title_short | Evaluation of Cinnamomum osmophloeum Kanehira Extracts on Tyrosinase Suppressor, Wound Repair Promoter, and Antioxidant |
| title_sort | evaluation of cinnamomum osmophloeum kanehira extracts on tyrosinase suppressor wound repair promoter and antioxidant |
| url | http://dx.doi.org/10.1155/2015/303415 |
| work_keys_str_mv | AT manganglee evaluationofcinnamomumosmophloeumkanehiraextractsontyrosinasesuppressorwoundrepairpromoterandantioxidant AT suyukuo evaluationofcinnamomumosmophloeumkanehiraextractsontyrosinasesuppressorwoundrepairpromoterandantioxidant AT shihyuyen evaluationofcinnamomumosmophloeumkanehiraextractsontyrosinasesuppressorwoundrepairpromoterandantioxidant AT hsiafenhsu evaluationofcinnamomumosmophloeumkanehiraextractsontyrosinasesuppressorwoundrepairpromoterandantioxidant AT chunghangleung evaluationofcinnamomumosmophloeumkanehiraextractsontyrosinasesuppressorwoundrepairpromoterandantioxidant AT diklungma evaluationofcinnamomumosmophloeumkanehiraextractsontyrosinasesuppressorwoundrepairpromoterandantioxidant AT zhihongwen evaluationofcinnamomumosmophloeumkanehiraextractsontyrosinasesuppressorwoundrepairpromoterandantioxidant AT huimindavidwang evaluationofcinnamomumosmophloeumkanehiraextractsontyrosinasesuppressorwoundrepairpromoterandantioxidant |