3D Bioprinting Strategies for Melatonin‐Loaded Polymers in Bone Tissue Engineering
Abstract Bone pathologies are still among the most challenging issues for orthopedics. Over the past decade, different methods are developed for bone repair. In addition to advanced surgical and graft techniques, polymer‐based biomaterials, bioactive glass, chitosan, hydrogels, nanoparticles, and ce...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-01-01
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| Series: | Macromolecular Materials and Engineering |
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| Online Access: | https://doi.org/10.1002/mame.202400263 |
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| author | Damla Aykora Ayhan Oral Cemre Aydeğer Metehan Uzun |
| author_facet | Damla Aykora Ayhan Oral Cemre Aydeğer Metehan Uzun |
| author_sort | Damla Aykora |
| collection | DOAJ |
| description | Abstract Bone pathologies are still among the most challenging issues for orthopedics. Over the past decade, different methods are developed for bone repair. In addition to advanced surgical and graft techniques, polymer‐based biomaterials, bioactive glass, chitosan, hydrogels, nanoparticles, and cell‐derived exosomes are used for bone healing strategies. Owing to their variation and promising advantages, most of these methods are not translated into clinical practice. Three dimensonal (3D) bioprinting is an additive manufacturing technique that has become a next‐generation biomaterial technique adapted for anatomic modeling, artificial tissue or organs, grafting, and bridging tissues. Polymer‐based biomaterials are mostly used for the controlled release of various drugs, therapeutic agents, mesenchymal stem cells, ions, and growth factors. Polymers are now among the most preferable materials for 3D bioprinting. Melatonin is a well‐known antioxidant with many osteoinductive properties and is one of the key hormones in the brain–bone axis. 3D bioprinted melatonin‐loaded polymers with unique lipophilic, anti‐inflammatory, antioxidant, and osteoinductive properties for filling large bone gaps following fractures or congenital bone deformities may be developed in the future. This study summarized the benefits of 3D bioprinted and polymeric materials integrated with melatonin for sustained release in bone regeneration approaches. |
| format | Article |
| id | doaj-art-7a2c8cb25d594b978a1055250bb6ee3e |
| institution | Kabale University |
| issn | 1438-7492 1439-2054 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Macromolecular Materials and Engineering |
| spelling | doaj-art-7a2c8cb25d594b978a1055250bb6ee3e2025-01-13T15:24:25ZengWiley-VCHMacromolecular Materials and Engineering1438-74921439-20542025-01-013101n/an/a10.1002/mame.2024002633D Bioprinting Strategies for Melatonin‐Loaded Polymers in Bone Tissue EngineeringDamla Aykora0Ayhan Oral1Cemre Aydeğer2Metehan Uzun3Vocational School of Health Services, Bitlis Eren University Bitlis 13000 TürkiyeFaculty of Science Department of Chemistry Çanakkale Onsekiz Mart University Çanakkale 17100 TürkiyeFaculty of Medicine Department of Physiology Çanakkale Onsekiz Mart University Çanakkale 17100 TürkiyeFaculty of Medicine Department of Physiology Çanakkale Onsekiz Mart University Çanakkale 17100 TürkiyeAbstract Bone pathologies are still among the most challenging issues for orthopedics. Over the past decade, different methods are developed for bone repair. In addition to advanced surgical and graft techniques, polymer‐based biomaterials, bioactive glass, chitosan, hydrogels, nanoparticles, and cell‐derived exosomes are used for bone healing strategies. Owing to their variation and promising advantages, most of these methods are not translated into clinical practice. Three dimensonal (3D) bioprinting is an additive manufacturing technique that has become a next‐generation biomaterial technique adapted for anatomic modeling, artificial tissue or organs, grafting, and bridging tissues. Polymer‐based biomaterials are mostly used for the controlled release of various drugs, therapeutic agents, mesenchymal stem cells, ions, and growth factors. Polymers are now among the most preferable materials for 3D bioprinting. Melatonin is a well‐known antioxidant with many osteoinductive properties and is one of the key hormones in the brain–bone axis. 3D bioprinted melatonin‐loaded polymers with unique lipophilic, anti‐inflammatory, antioxidant, and osteoinductive properties for filling large bone gaps following fractures or congenital bone deformities may be developed in the future. This study summarized the benefits of 3D bioprinted and polymeric materials integrated with melatonin for sustained release in bone regeneration approaches.https://doi.org/10.1002/mame.2024002633D bioprintingbone diseasesbone regenerationbone tissue engineeringmelatoninpolymers |
| spellingShingle | Damla Aykora Ayhan Oral Cemre Aydeğer Metehan Uzun 3D Bioprinting Strategies for Melatonin‐Loaded Polymers in Bone Tissue Engineering Macromolecular Materials and Engineering 3D bioprinting bone diseases bone regeneration bone tissue engineering melatonin polymers |
| title | 3D Bioprinting Strategies for Melatonin‐Loaded Polymers in Bone Tissue Engineering |
| title_full | 3D Bioprinting Strategies for Melatonin‐Loaded Polymers in Bone Tissue Engineering |
| title_fullStr | 3D Bioprinting Strategies for Melatonin‐Loaded Polymers in Bone Tissue Engineering |
| title_full_unstemmed | 3D Bioprinting Strategies for Melatonin‐Loaded Polymers in Bone Tissue Engineering |
| title_short | 3D Bioprinting Strategies for Melatonin‐Loaded Polymers in Bone Tissue Engineering |
| title_sort | 3d bioprinting strategies for melatonin loaded polymers in bone tissue engineering |
| topic | 3D bioprinting bone diseases bone regeneration bone tissue engineering melatonin polymers |
| url | https://doi.org/10.1002/mame.202400263 |
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