Slug increases sensitivity to tubulin‐binding agents via the downregulation of βIII and βIVa‐tubulin in lung cancer cells

Slug increases sensitivity to tubulin‐binding agents via the downregulation of βIII and βIVa‐tubulin in lung cancer cells

Abstract Transcription factor Slug/SNAI2 (snail homolog 2) plays a key role in the induction of the epithelial mesenchymal transition in cancer cells; however, whether the overexpression of Slug mediates the malignant phenotype and alters drug sensitivity in lung cancer cells remains largely unclear...

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Main Authors: Daisuke Tamura, Tokuzo Arao, Tomoyuki Nagai, Hiroyasu Kaneda, Keiichi Aomatsu, Yoshihiko Fujita, Kazuko Matsumoto, Marco A. DeVelasco, Hiroaki Kato, Hidetoshi Hayashi, Shuhei Yoshida, Hideharu Kimura, Yoshimasa Maniwa, Wataru Nishio, Yasuhiro Sakai, Chiho Ohbayashi, Yoshikazu Kotani, Yoshihiro Nishimura, Kazuto Nishio
Format: Article
Language:English
Published: Wiley 2013-04-01
Series:Cancer Medicine
Subjects:
Anoikis
lung cancer
slug
tubulin‐binding agents
tumor growth
Online Access:https://doi.org/10.1002/cam4.68
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