Global Incidence Trend of Early-Onset Obesity-Related and Non-Obesity-Related Cancers
The global rise in obesity prevalence and the incidence of early-onset cancer (diagnosed between 20 and 49 years of age) is a serious public health concern. We, therefore, evaluated the recent global trends in the incidence of early-onset obesity-related cancers and compared them to those of non-obe...
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MDPI AG
2025-05-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/32/6/324 |
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| author | Miyu Terashima Kota Nakayama Satoko Ugai Hwa-Young Lee Yuta Tsukumo Etsuji Suzuki Hiroki Mizuno Minkyo Song Naoko Sasamoto Ichiro Kawachi Tomotaka Ugai |
| author_facet | Miyu Terashima Kota Nakayama Satoko Ugai Hwa-Young Lee Yuta Tsukumo Etsuji Suzuki Hiroki Mizuno Minkyo Song Naoko Sasamoto Ichiro Kawachi Tomotaka Ugai |
| author_sort | Miyu Terashima |
| collection | DOAJ |
| description | The global rise in obesity prevalence and the incidence of early-onset cancer (diagnosed between 20 and 49 years of age) is a serious public health concern. We, therefore, evaluated the recent global trends in the incidence of early-onset obesity-related cancers and compared them to those of non-obesity-related cancers. We obtained age-standardized incidence rates of early-onset cancers diagnosed between 2000 and 2012 in 44 countries from the Cancer Incidence in Five Continents database. Using joinpoint regression models, we calculated the average annual percentage changes (AAPCs) and their corresponding 95% confidence intervals (95% CIs) for combined and individual categories of obesity-related cancers (11 and 9 cancer types in females and males, respectively) and non-obesity-related cancers (12 cancer types in both females and males). Differences in the AAPC were assessed by comparing 95% CIs, where nonoverlapping 95% CIs were considered statistically significantly different. We observed statistically significant positive AAPCs for early-onset obesity-related cancers in all available countries combined among females (global AAPC, 4.3%; 95% CI, 4.1–4.6%) and males (global AAPC, 1.4%; 95% CI, 1.2–1.7%). When analyzed by countries, we observed statistically significant positive AAPCs in 26 countries among females and 11 countries among males. AAPCs for early-onset obesity-related cancers were statistically significantly higher than those of non-obesity-related cancers in several regions, especially North America and Oceania. In conclusion, this study indicates that the incidence of early-onset obesity-related cancers exhibited a more pronounced increasing trend than non-obesity-related cancers among both sexes in many countries and regions. |
| format | Article |
| id | doaj-art-7a2b62d8f4a64bbd941359e14b3029cb |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-7a2b62d8f4a64bbd941359e14b3029cb2025-08-20T03:27:28ZengMDPI AGCurrent Oncology1198-00521718-77292025-05-0132632410.3390/curroncol32060324Global Incidence Trend of Early-Onset Obesity-Related and Non-Obesity-Related CancersMiyu Terashima0Kota Nakayama1Satoko Ugai2Hwa-Young Lee3Yuta Tsukumo4Etsuji Suzuki5Hiroki Mizuno6Minkyo Song7Naoko Sasamoto8Ichiro Kawachi9Tomotaka Ugai10Okayama University Medical School, Okayama 700-8558, JapanOkayama University Medical School, Okayama 700-8558, JapanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USAGraduate School of Public Health and Healthcare Management, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USADepartment of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, JapanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USALaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USAPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USADepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USADepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USAThe global rise in obesity prevalence and the incidence of early-onset cancer (diagnosed between 20 and 49 years of age) is a serious public health concern. We, therefore, evaluated the recent global trends in the incidence of early-onset obesity-related cancers and compared them to those of non-obesity-related cancers. We obtained age-standardized incidence rates of early-onset cancers diagnosed between 2000 and 2012 in 44 countries from the Cancer Incidence in Five Continents database. Using joinpoint regression models, we calculated the average annual percentage changes (AAPCs) and their corresponding 95% confidence intervals (95% CIs) for combined and individual categories of obesity-related cancers (11 and 9 cancer types in females and males, respectively) and non-obesity-related cancers (12 cancer types in both females and males). Differences in the AAPC were assessed by comparing 95% CIs, where nonoverlapping 95% CIs were considered statistically significantly different. We observed statistically significant positive AAPCs for early-onset obesity-related cancers in all available countries combined among females (global AAPC, 4.3%; 95% CI, 4.1–4.6%) and males (global AAPC, 1.4%; 95% CI, 1.2–1.7%). When analyzed by countries, we observed statistically significant positive AAPCs in 26 countries among females and 11 countries among males. AAPCs for early-onset obesity-related cancers were statistically significantly higher than those of non-obesity-related cancers in several regions, especially North America and Oceania. In conclusion, this study indicates that the incidence of early-onset obesity-related cancers exhibited a more pronounced increasing trend than non-obesity-related cancers among both sexes in many countries and regions.https://www.mdpi.com/1718-7729/32/6/324neoplasmsetiologyrisk factorsglobal healthyoung adults |
| spellingShingle | Miyu Terashima Kota Nakayama Satoko Ugai Hwa-Young Lee Yuta Tsukumo Etsuji Suzuki Hiroki Mizuno Minkyo Song Naoko Sasamoto Ichiro Kawachi Tomotaka Ugai Global Incidence Trend of Early-Onset Obesity-Related and Non-Obesity-Related Cancers Current Oncology neoplasms etiology risk factors global health young adults |
| title | Global Incidence Trend of Early-Onset Obesity-Related and Non-Obesity-Related Cancers |
| title_full | Global Incidence Trend of Early-Onset Obesity-Related and Non-Obesity-Related Cancers |
| title_fullStr | Global Incidence Trend of Early-Onset Obesity-Related and Non-Obesity-Related Cancers |
| title_full_unstemmed | Global Incidence Trend of Early-Onset Obesity-Related and Non-Obesity-Related Cancers |
| title_short | Global Incidence Trend of Early-Onset Obesity-Related and Non-Obesity-Related Cancers |
| title_sort | global incidence trend of early onset obesity related and non obesity related cancers |
| topic | neoplasms etiology risk factors global health young adults |
| url | https://www.mdpi.com/1718-7729/32/6/324 |
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