Combined eosinophilic gastroenteritis and ulcerative colitis successfully treated by vedolizumab: a case report
A 47-year-old man with over 10 years’ duration of ulcerative colitis treated by 5-aminosalicylic acid and intermittent topical steroids complained of acute epigastric pain. Esophagogastroduodenoscopy revealed diffuse mucosal edema with patchy redness, multiple erosions and nodularity of the stomach....
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of Intestinal Diseases
2025-01-01
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| Series: | Intestinal Research |
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| Online Access: | http://irjournal.org/upload/pdf/ir-2024-00013.pdf |
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| author | Hironobu Takedomi Kayoko Fukuda Suma Inoue Nanae Tsuruoka Yasuhisa Sakata Shigehisa Aoki Motohiro Esaki |
| author_facet | Hironobu Takedomi Kayoko Fukuda Suma Inoue Nanae Tsuruoka Yasuhisa Sakata Shigehisa Aoki Motohiro Esaki |
| author_sort | Hironobu Takedomi |
| collection | DOAJ |
| description | A 47-year-old man with over 10 years’ duration of ulcerative colitis treated by 5-aminosalicylic acid and intermittent topical steroids complained of acute epigastric pain. Esophagogastroduodenoscopy revealed diffuse mucosal edema with patchy redness, multiple erosions and nodularity of the stomach. Bioptic examination revealed marked eosinophilic infiltration, confirming the diagnosis of eosinophilic gastroenteritis. Systemic steroid therapy was initiated, whereas his ulcerative colitis and eosinophilia recurred when tapering the steroid. Addition of azathioprine was ineffective, and we subsequently started vedolizumab for eosinophilic gastroenteritis and ulcerative colitis. The medication effectively improved his abdominal symptoms and esophagogastroduodenoscopy and ileocolonoscopy 1 year later revealed endoscopic improvement of both diseases with histologically decreased level of eosinophilic infiltration. Considering that eosinophils also express α4β7 integrins, vedolizumab can be a possible therapeutic candidate for eosinophilic gastroenteritis as well as ulcerative colitis. |
| format | Article |
| id | doaj-art-7a29903f94ec4fcf9ea9fb364fc9b8c1 |
| institution | DOAJ |
| issn | 1598-9100 2288-1956 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Association for the Study of Intestinal Diseases |
| record_format | Article |
| series | Intestinal Research |
| spelling | doaj-art-7a29903f94ec4fcf9ea9fb364fc9b8c12025-08-20T03:07:58ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002288-19562025-01-0123110711110.5217/ir.2024.000131081Combined eosinophilic gastroenteritis and ulcerative colitis successfully treated by vedolizumab: a case reportHironobu Takedomi0Kayoko Fukuda1Suma Inoue2Nanae Tsuruoka3Yasuhisa Sakata4Shigehisa Aoki5Motohiro Esaki6 Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan Department of Gastroenterology, Hiramatsu Hospital, Ogi, Japan Department of Gastroenterology, Hiramatsu Hospital, Ogi, Japan Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan Division of Pathology, Department of Pathology and Microbiology, Faculty of Medicine, Saga University, Saga, Japan Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, JapanA 47-year-old man with over 10 years’ duration of ulcerative colitis treated by 5-aminosalicylic acid and intermittent topical steroids complained of acute epigastric pain. Esophagogastroduodenoscopy revealed diffuse mucosal edema with patchy redness, multiple erosions and nodularity of the stomach. Bioptic examination revealed marked eosinophilic infiltration, confirming the diagnosis of eosinophilic gastroenteritis. Systemic steroid therapy was initiated, whereas his ulcerative colitis and eosinophilia recurred when tapering the steroid. Addition of azathioprine was ineffective, and we subsequently started vedolizumab for eosinophilic gastroenteritis and ulcerative colitis. The medication effectively improved his abdominal symptoms and esophagogastroduodenoscopy and ileocolonoscopy 1 year later revealed endoscopic improvement of both diseases with histologically decreased level of eosinophilic infiltration. Considering that eosinophils also express α4β7 integrins, vedolizumab can be a possible therapeutic candidate for eosinophilic gastroenteritis as well as ulcerative colitis.http://irjournal.org/upload/pdf/ir-2024-00013.pdfeosinophilic gastroenteritisulcerative colitisα4β7 integrinvedolizumabcase reports |
| spellingShingle | Hironobu Takedomi Kayoko Fukuda Suma Inoue Nanae Tsuruoka Yasuhisa Sakata Shigehisa Aoki Motohiro Esaki Combined eosinophilic gastroenteritis and ulcerative colitis successfully treated by vedolizumab: a case report Intestinal Research eosinophilic gastroenteritis ulcerative colitis α4β7 integrin vedolizumab case reports |
| title | Combined eosinophilic gastroenteritis and ulcerative colitis successfully treated by vedolizumab: a case report |
| title_full | Combined eosinophilic gastroenteritis and ulcerative colitis successfully treated by vedolizumab: a case report |
| title_fullStr | Combined eosinophilic gastroenteritis and ulcerative colitis successfully treated by vedolizumab: a case report |
| title_full_unstemmed | Combined eosinophilic gastroenteritis and ulcerative colitis successfully treated by vedolizumab: a case report |
| title_short | Combined eosinophilic gastroenteritis and ulcerative colitis successfully treated by vedolizumab: a case report |
| title_sort | combined eosinophilic gastroenteritis and ulcerative colitis successfully treated by vedolizumab a case report |
| topic | eosinophilic gastroenteritis ulcerative colitis α4β7 integrin vedolizumab case reports |
| url | http://irjournal.org/upload/pdf/ir-2024-00013.pdf |
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