Resting fMRI-guided TMS evokes subgenual anterior cingulate response in depression
Background: Depression alleviation following treatment with repetitive transcranial magnetic stimulation (rTMS) tends to be more effective when TMS is targeted to cortical areas with high (negative) resting state functional connectivity (rsFC) with the subgenual anterior cingulate cortex (sgACC). Ho...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811924004609 |
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| author | Romain J. Duprat Kristin A. Linn Theodore D. Satterthwaite Yvette I. Sheline Ximo Liang Gabriela Bagdon Matthew W. Flounders Heather Robinson Michael Platt Joseph Kable Hannah Long Morgan Scully Joseph A. Deluisi Michael Thase Mario Cristancho Julie Grier Camille Blaine Almaris Figueroa-González Desmond J. Oathes |
| author_facet | Romain J. Duprat Kristin A. Linn Theodore D. Satterthwaite Yvette I. Sheline Ximo Liang Gabriela Bagdon Matthew W. Flounders Heather Robinson Michael Platt Joseph Kable Hannah Long Morgan Scully Joseph A. Deluisi Michael Thase Mario Cristancho Julie Grier Camille Blaine Almaris Figueroa-González Desmond J. Oathes |
| author_sort | Romain J. Duprat |
| collection | DOAJ |
| description | Background: Depression alleviation following treatment with repetitive transcranial magnetic stimulation (rTMS) tends to be more effective when TMS is targeted to cortical areas with high (negative) resting state functional connectivity (rsFC) with the subgenual anterior cingulate cortex (sgACC). However, the relationship between sgACC-cortex rsFC and the TMS-evoked response in the sgACC is still being explored and has not yet been established in depressed patients. Objectives: In this study, we investigated the relationship between sgACC-cortical (site of stimulation) rsFC and induced evoked responses in the sgACC in healthy controls and depressed patients. Methods: For each participant (N = 115, 34 depressed patients), a peak rsFC cortical ‘hotspot’ for the sgACC and control targets were identified at baseline. Single pulses of TMS interleaved with fMRI readouts were administered to these targets to evoke downstream fMRI blood-oxygen-level-dependent (BOLD) responses in the sgACC. Generalized estimating equations were used to investigate the association between TMS-evoked BOLD responses in the sgACC and rsFC between the stimulation site and the sgACC. Results: Stimulations over cortical sites with high rsFC to the sgACC were effective in modulating activity in the sgACC in both healthy controls and depressed patients. Moreover, we found that in depressed patients, sgACC rsFC at the site of stimulation was associated with the induced evoked response amplitude in the sgACC: stronger positive rsFC values leading to stronger evoked responses in the sgACC. Conclusions: rsFC-based targeting is a viable strategy to causally modulate the sgACC. Assuming an anti-depressive mechanism working through modulation of the sgACC, the field's exclusive focus on sites anticorrelated with the sgACC for treating depression should be broadened to explore positively-connected sites. |
| format | Article |
| id | doaj-art-7a2780a06d2b490e8b1919c5cf651cf8 |
| institution | Kabale University |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | NeuroImage |
| spelling | doaj-art-7a2780a06d2b490e8b1919c5cf651cf82025-01-11T06:38:31ZengElsevierNeuroImage1095-95722025-01-01305120963Resting fMRI-guided TMS evokes subgenual anterior cingulate response in depressionRomain J. Duprat0Kristin A. Linn1Theodore D. Satterthwaite2Yvette I. Sheline3Ximo Liang4Gabriela Bagdon5Matthew W. Flounders6Heather Robinson7Michael Platt8Joseph Kable9Hannah Long10Morgan Scully11Joseph A. Deluisi12Michael Thase13Mario Cristancho14Julie Grier15Camille Blaine16Almaris Figueroa-González17Desmond J. Oathes18Center for Brain Imaging and Stimulation, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, USA; Center for the Neuromodulation of Depression and Stress, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USACenter for Brain Imaging and Stimulation, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, USA; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Perelman School of Medicine, Department of Biostatistics, Epidemiology, and Informatics, Philadelphia, PA, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA; The Penn Statistics in Imaging and Visualization Endeavor, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Perelman School of Medicine, Department of Biostatistics, Epidemiology, and Informatics, Philadelphia, PA, USAUniversity of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USA; Penn Lifespan Informatics and Neuroimaging Center, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USACenter for the Neuromodulation of Depression and Stress, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USACenter for Brain Imaging and Stimulation, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, USA; Center for the Neuromodulation of Depression and Stress, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USACenter for Brain Imaging and Stimulation, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, USA; Center for the Neuromodulation of Depression and Stress, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USACenter for Brain Imaging and Stimulation, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, USA; Center for the Neuromodulation of Depression and Stress, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USACenter for Brain Imaging and Stimulation, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, USA; Center for the Neuromodulation of Depression and Stress, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USAUniversity of Pennsylvania, Department of Psychology, Philadelphia, PA, USA; University of Pennsylvania, Department of Neuroscience, Philadelphia, PA, USA; University of Pennsylvania, Department of Marketing, Philadelphia, PA, USAUniversity of Pennsylvania, Department of Psychology, Philadelphia, PA, USACenter for Brain Imaging and Stimulation, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, USA; Center for the Neuromodulation of Depression and Stress, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USACenter for Brain Imaging and Stimulation, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, USA; Center for the Neuromodulation of Depression and Stress, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USACenter for Brain Imaging and Stimulation, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, USA; Center for the Neuromodulation of Depression and Stress, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USAUniversity of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USAUniversity of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USACenter for Brain Imaging and Stimulation, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, USA; Center for the Neuromodulation of Depression and Stress, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USACenter for Brain Imaging and Stimulation, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, USA; Center for the Neuromodulation of Depression and Stress, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USACenter for Brain Imaging and Stimulation, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, USA; Center for the Neuromodulation of Depression and Stress, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USACenter for Brain Imaging and Stimulation, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, USA; Center for the Neuromodulation of Depression and Stress, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Penn Brain Science, Translation, Innovation, and Modulation Center, Philadelphia, PA, USA; Corresponding author at: Richards Biomedical Building, D306, 3700 Hamilton Walk, Philadelphia, PA 19104, USA.Background: Depression alleviation following treatment with repetitive transcranial magnetic stimulation (rTMS) tends to be more effective when TMS is targeted to cortical areas with high (negative) resting state functional connectivity (rsFC) with the subgenual anterior cingulate cortex (sgACC). However, the relationship between sgACC-cortex rsFC and the TMS-evoked response in the sgACC is still being explored and has not yet been established in depressed patients. Objectives: In this study, we investigated the relationship between sgACC-cortical (site of stimulation) rsFC and induced evoked responses in the sgACC in healthy controls and depressed patients. Methods: For each participant (N = 115, 34 depressed patients), a peak rsFC cortical ‘hotspot’ for the sgACC and control targets were identified at baseline. Single pulses of TMS interleaved with fMRI readouts were administered to these targets to evoke downstream fMRI blood-oxygen-level-dependent (BOLD) responses in the sgACC. Generalized estimating equations were used to investigate the association between TMS-evoked BOLD responses in the sgACC and rsFC between the stimulation site and the sgACC. Results: Stimulations over cortical sites with high rsFC to the sgACC were effective in modulating activity in the sgACC in both healthy controls and depressed patients. Moreover, we found that in depressed patients, sgACC rsFC at the site of stimulation was associated with the induced evoked response amplitude in the sgACC: stronger positive rsFC values leading to stronger evoked responses in the sgACC. Conclusions: rsFC-based targeting is a viable strategy to causally modulate the sgACC. Assuming an anti-depressive mechanism working through modulation of the sgACC, the field's exclusive focus on sites anticorrelated with the sgACC for treating depression should be broadened to explore positively-connected sites.http://www.sciencedirect.com/science/article/pii/S1053811924004609TMSfMRIFunctional connectivitysgACCDepression |
| spellingShingle | Romain J. Duprat Kristin A. Linn Theodore D. Satterthwaite Yvette I. Sheline Ximo Liang Gabriela Bagdon Matthew W. Flounders Heather Robinson Michael Platt Joseph Kable Hannah Long Morgan Scully Joseph A. Deluisi Michael Thase Mario Cristancho Julie Grier Camille Blaine Almaris Figueroa-González Desmond J. Oathes Resting fMRI-guided TMS evokes subgenual anterior cingulate response in depression NeuroImage TMS fMRI Functional connectivity sgACC Depression |
| title | Resting fMRI-guided TMS evokes subgenual anterior cingulate response in depression |
| title_full | Resting fMRI-guided TMS evokes subgenual anterior cingulate response in depression |
| title_fullStr | Resting fMRI-guided TMS evokes subgenual anterior cingulate response in depression |
| title_full_unstemmed | Resting fMRI-guided TMS evokes subgenual anterior cingulate response in depression |
| title_short | Resting fMRI-guided TMS evokes subgenual anterior cingulate response in depression |
| title_sort | resting fmri guided tms evokes subgenual anterior cingulate response in depression |
| topic | TMS fMRI Functional connectivity sgACC Depression |
| url | http://www.sciencedirect.com/science/article/pii/S1053811924004609 |
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