Low Levels of Sex Hormone-Binding Globulin Constitute an Independent Risk Factor for Arterial Stiffness in Korean Women
The association between sex hormone-binding globulin (SHBG) and arterial stiffness in women is not conclusive. In addition, obesity might also be involved in the relationship between SHBG and atherosclerosis. The aim of this study was to determine the relationship between SHBG and arterial stiffness...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/6956495 |
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| author | Kunhee Han Hyejin Chun Moon-Jong Kim Doo-Yeoun Cho Soo-Hyun Lee Bo Youn Won Kwang-Min Kim Nam-Seok Joo Young-Sang Kim |
| author_facet | Kunhee Han Hyejin Chun Moon-Jong Kim Doo-Yeoun Cho Soo-Hyun Lee Bo Youn Won Kwang-Min Kim Nam-Seok Joo Young-Sang Kim |
| author_sort | Kunhee Han |
| collection | DOAJ |
| description | The association between sex hormone-binding globulin (SHBG) and arterial stiffness in women is not conclusive. In addition, obesity might also be involved in the relationship between SHBG and atherosclerosis. The aim of this study was to determine the relationship between SHBG and arterial stiffness in association with central obesity in women. This cross-sectional study included 381 women who participated in the health checkup programs in one hospital. The brachial-ankle pulse wave velocity (baPWV) was measured as a marker for arterial stiffness. A negative correlation was observed between SHBG levels and baPWV (rho = −0.281). The relationship was significant even after adjusting for potential confounders (beta = −0.087 in fully adjusted model). After considering the interaction between central obesity and SHBG levels, the significant association was evident only in obese women (P for interaction = 0.025). Adjustment for a 10-year atherosclerotic cardiovascular disease (ASCVD) risk scores, instead of each cardiovascular risk factor individually, did not affect the significance of the relationship between SHBG levels and baPWV. Serum levels of SHBG were negatively associated with arterial stiffness independent of cardiovascular risk factors or 10-year ASCVD risk scores in Korean women. The relationship may be potentiated by central obesity. |
| format | Article |
| id | doaj-art-7a27515164e94f1daac7d9380d3630fc |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-7a27515164e94f1daac7d9380d3630fc2025-02-03T01:30:11ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/69564956956495Low Levels of Sex Hormone-Binding Globulin Constitute an Independent Risk Factor for Arterial Stiffness in Korean WomenKunhee Han0Hyejin Chun1Moon-Jong Kim2Doo-Yeoun Cho3Soo-Hyun Lee4Bo Youn Won5Kwang-Min Kim6Nam-Seok Joo7Young-Sang Kim8Department of Family Medicine, CHA Bundang Medical Centre, CHA University, Seongnam 13496, Republic of KoreaDepartment of Family Medicine, CHA Bundang Medical Centre, CHA University, Seongnam 13496, Republic of KoreaDepartment of Family Medicine, CHA Bundang Medical Centre, CHA University, Seongnam 13496, Republic of KoreaDepartment of Clinical Pharmacology, CHA Bundang Medical Centre, CHA University, Seongnam 13496, Republic of KoreaDepartment of Family Medicine, CHA Bundang Medical Centre, CHA University, Seongnam 13496, Republic of KoreaDepartment of Family Medicine, CHA Bundang Medical Centre, CHA University, Seongnam 13496, Republic of KoreaDepartment of Family Medicine and Community Health, Ajou University, Suwon 16499, Republic of KoreaDepartment of Family Medicine and Community Health, Ajou University, Suwon 16499, Republic of KoreaDepartment of Family Medicine, CHA Bundang Medical Centre, CHA University, Seongnam 13496, Republic of KoreaThe association between sex hormone-binding globulin (SHBG) and arterial stiffness in women is not conclusive. In addition, obesity might also be involved in the relationship between SHBG and atherosclerosis. The aim of this study was to determine the relationship between SHBG and arterial stiffness in association with central obesity in women. This cross-sectional study included 381 women who participated in the health checkup programs in one hospital. The brachial-ankle pulse wave velocity (baPWV) was measured as a marker for arterial stiffness. A negative correlation was observed between SHBG levels and baPWV (rho = −0.281). The relationship was significant even after adjusting for potential confounders (beta = −0.087 in fully adjusted model). After considering the interaction between central obesity and SHBG levels, the significant association was evident only in obese women (P for interaction = 0.025). Adjustment for a 10-year atherosclerotic cardiovascular disease (ASCVD) risk scores, instead of each cardiovascular risk factor individually, did not affect the significance of the relationship between SHBG levels and baPWV. Serum levels of SHBG were negatively associated with arterial stiffness independent of cardiovascular risk factors or 10-year ASCVD risk scores in Korean women. The relationship may be potentiated by central obesity.http://dx.doi.org/10.1155/2017/6956495 |
| spellingShingle | Kunhee Han Hyejin Chun Moon-Jong Kim Doo-Yeoun Cho Soo-Hyun Lee Bo Youn Won Kwang-Min Kim Nam-Seok Joo Young-Sang Kim Low Levels of Sex Hormone-Binding Globulin Constitute an Independent Risk Factor for Arterial Stiffness in Korean Women International Journal of Endocrinology |
| title | Low Levels of Sex Hormone-Binding Globulin Constitute an Independent Risk Factor for Arterial Stiffness in Korean Women |
| title_full | Low Levels of Sex Hormone-Binding Globulin Constitute an Independent Risk Factor for Arterial Stiffness in Korean Women |
| title_fullStr | Low Levels of Sex Hormone-Binding Globulin Constitute an Independent Risk Factor for Arterial Stiffness in Korean Women |
| title_full_unstemmed | Low Levels of Sex Hormone-Binding Globulin Constitute an Independent Risk Factor for Arterial Stiffness in Korean Women |
| title_short | Low Levels of Sex Hormone-Binding Globulin Constitute an Independent Risk Factor for Arterial Stiffness in Korean Women |
| title_sort | low levels of sex hormone binding globulin constitute an independent risk factor for arterial stiffness in korean women |
| url | http://dx.doi.org/10.1155/2017/6956495 |
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