Sirtuins in kidney homeostasis and disease: where are we now?
Sirtuins, identified as (NAD+)- dependent class III histone deacetylases, engage in a spectrum of biological functions, encompassing DNA damage repair, oxidative stress, immune modulation, mitochondrial homeostasis, apoptosis and autophagy. Sirtuins play an apoptosis role in regulating cellular oper...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1524674/full |
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| author | Zhongyu Fan Xuejiao Wei Xiaoyu Zhu Yujun Du |
| author_facet | Zhongyu Fan Xuejiao Wei Xiaoyu Zhu Yujun Du |
| author_sort | Zhongyu Fan |
| collection | DOAJ |
| description | Sirtuins, identified as (NAD+)- dependent class III histone deacetylases, engage in a spectrum of biological functions, encompassing DNA damage repair, oxidative stress, immune modulation, mitochondrial homeostasis, apoptosis and autophagy. Sirtuins play an apoptosis role in regulating cellular operations and overall organism health. Mounting data indicate that dysregulated sirtuin expression is linked to the onset of renal diseases. Effective modulation of sirtuins expression and activity has been shown to improve renal function and attenuate the advancement of kidney diseases. In this review, we present a comprehensive overview of the biological impacts of sirtuins and their molecular targets in regulating renal diseases. Additionally, we detail advancements in elucidating sirtuin roles in the pathophysiology of both chronic and acute renal disorders. We review compounds that modulate sirtuin activity through activation or inhibition, potentially improving outcomes in renal disease. In summary, strategic manipulation of sirtuin activity represents a prospective therapeutic approach for renal diseases. |
| format | Article |
| id | doaj-art-7a2128d3711042179138177e27d3a6a4 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-7a2128d3711042179138177e27d3a6a42025-01-22T05:19:26ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.15246741524674Sirtuins in kidney homeostasis and disease: where are we now?Zhongyu FanXuejiao WeiXiaoyu ZhuYujun DuSirtuins, identified as (NAD+)- dependent class III histone deacetylases, engage in a spectrum of biological functions, encompassing DNA damage repair, oxidative stress, immune modulation, mitochondrial homeostasis, apoptosis and autophagy. Sirtuins play an apoptosis role in regulating cellular operations and overall organism health. Mounting data indicate that dysregulated sirtuin expression is linked to the onset of renal diseases. Effective modulation of sirtuins expression and activity has been shown to improve renal function and attenuate the advancement of kidney diseases. In this review, we present a comprehensive overview of the biological impacts of sirtuins and their molecular targets in regulating renal diseases. Additionally, we detail advancements in elucidating sirtuin roles in the pathophysiology of both chronic and acute renal disorders. We review compounds that modulate sirtuin activity through activation or inhibition, potentially improving outcomes in renal disease. In summary, strategic manipulation of sirtuin activity represents a prospective therapeutic approach for renal diseases.https://www.frontiersin.org/articles/10.3389/fendo.2024.1524674/fullsirtuinschronic kidney diseaseacute kidney injurymitochondriainflammationoxidative stress |
| spellingShingle | Zhongyu Fan Xuejiao Wei Xiaoyu Zhu Yujun Du Sirtuins in kidney homeostasis and disease: where are we now? Frontiers in Endocrinology sirtuins chronic kidney disease acute kidney injury mitochondria inflammation oxidative stress |
| title | Sirtuins in kidney homeostasis and disease: where are we now? |
| title_full | Sirtuins in kidney homeostasis and disease: where are we now? |
| title_fullStr | Sirtuins in kidney homeostasis and disease: where are we now? |
| title_full_unstemmed | Sirtuins in kidney homeostasis and disease: where are we now? |
| title_short | Sirtuins in kidney homeostasis and disease: where are we now? |
| title_sort | sirtuins in kidney homeostasis and disease where are we now |
| topic | sirtuins chronic kidney disease acute kidney injury mitochondria inflammation oxidative stress |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1524674/full |
| work_keys_str_mv | AT zhongyufan sirtuinsinkidneyhomeostasisanddiseasewherearewenow AT xuejiaowei sirtuinsinkidneyhomeostasisanddiseasewherearewenow AT xiaoyuzhu sirtuinsinkidneyhomeostasisanddiseasewherearewenow AT yujundu sirtuinsinkidneyhomeostasisanddiseasewherearewenow |